ArticleExperimental neurology2008
Immune activation is required for NT-3-induced axonal plasticity in chronic spinal cord injury.
Article in Experimental neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
- Reawakening inflammation in the chronically injured spinal cord using lipopolysaccharide induces diverse microglial states.Journal of neuroinflammation · 2025Article
- Low-Dose LPS Modulates Microglia/Macrophages Phenotypic Transformation to Amplify Rehabilitation Effects in Chronic Spinal Cord Injured (CSCI) Mice.Molecular neurobiology · 2024Article
- Review
- The neuroanatomical-functional paradox in spinal cord injury.Nature reviews. Neurology · 2021Review
- Treatment with Tang-luo-ning altered the microRNA expression profile in rats with diabetic peripheral neuropathy.Bioengineered · 2020Article
- Neuroimmune System as a Driving Force for Plasticity Following CNS Injury.Frontiers in cellular neuroscience · 2020Review
- Neuronal activity and microglial activation support corticospinal tract and proprioceptive afferent sprouting in spinal circuits after a corticospinal system lesion.Experimental neurology · 2019Article
- The benefits of neuroinflammation for the repair of the injured central nervous system.Cellular & molecular immunology · 2019Review
- Stroke Recovery in Rats after 24-Hour-Delayed Intramuscular Neurotrophin-3 Infusion.Annals of neurology · 2019Article
- A Potential Competitive Endogenous RNA Pathway Involved in Chronic Spinal Cord Injury.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Eliciting inflammation enables successful rehabilitative training in chronic spinal cord injury.Brain : a journal of neurology · 2018Article
- A growing field: The regulation of axonal regeneration by Wnt signaling.Neural regeneration research · 2018Review
- Tail Nerve Electrical Stimulation and Electro-Acupuncture Can Protect Spinal Motor Neurons and Alleviate Muscle Atrophy after Spinal Cord Transection in Rats.Neural plasticity · 2017Article
- Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke.Brain : a journal of neurology · 2016Article
- Unilateral pyramidotomy of the corticospinal tract in rats for assessment of neuroplasticity-inducing therapies.Journal of visualized experiments : JoVE · 2014Article
- Tissue engineering is a promising method for the repair of spinal cord injuries (Review).Experimental and therapeutic medicine · 2014Article
- Neutrophils express oncomodulin and promote optic nerve regeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
- Article
- Selective corticospinal tract injury in the rat induces primary afferent fiber sprouting in the spinal cord and hyperreflexia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
After an unilateral lesion of the corticospinal tract (CST) at the level of the medulla over-expression of Neurotrophin-3 (NT-3) in lumbar spinal cord motoneurons induced axonal sprouting of the intact CST in the acutely injured but not uninjured or chronically injured spinal cord in rats. This suggested that processes associated with immune-mediated wound healing may act with NT-3 to induce neuroplasticity. To test whether immune processes were involved we measured NT-3-induced axonal sprouting in immunosuppressed compared to immunocompetent rats. Rats were immunosuppressed with anti-leukocyte antibodies 1 day before receiving a CST lesion and then 2 weeks later NT-3 was over-expressed in the lumbar spinal motoneurons with an adenoviral vector carrying the NT-3 gene targeted to the motoneurons by retrograde transport. At 35 days post-lesion no axonal sprouting was measured in immunosuppressed rats whereas axonal sprouting was measured in the immunocompetent rats. We then tested whether re-evoking an immune response in chronically lesioned rats would induce neuroplasticity. Rats received CST lesions and then 4 months later were treated with systemic injections of lipopolysaccharide (LPS) 7 days before NT-3 was over-expressed in the lumbar spinal motoneurons. Axonal sprouting was observed in the LPS treated rats but not in control animals that were not treated with LPS. Further studies showed that lesioning the CST activated and LPS reactivated microglia and CD4(+) T-cells in the acutely lesioned and chronically lesioned rats, respectively. However, immunosuppression only decreased the number of activated CD4(+) T-cells suggesting they were responsible for the support of axonal growth. These observations demonstrate that processes associated with immune-mediated wound healing play a role in NT-3-induced neuroplasticity after injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.