ArticleBiochimica et biophysica acta2008
Terminal RNA uridylyltransferases of trypanosomes.
Article in Biochimica et biophysica acta, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Organization of minicircle cassettes and guide RNA genes inRNA (New York, N.Y.) · 2022Article
- Comparison of the Mitochondrial Genomes and Steady State Transcriptomes of Two Strains of the Trypanosomatid Parasite, Leishmania tarentolae.PLoS neglected tropical diseases · 2015Article
- Polyuridylation in Eukaryotes: A 3'-End Modification Regulating RNA Life.BioMed research international · 2015Review
- Elements of nucleotide specificity in the Trypanosoma brucei mitochondrial RNA editing enzyme RET2.Journal of chemical information and modeling · 2012Article
- Mitochondrial RNA processing in trypanosomes.Research in microbiology · 2011Review
- Complete set of mitochondrial pan-edited mRNAs in Leishmania mexicana amazonensis LV78.Molecular and biochemical parasitology · 2010Article
- Mechanism of U-insertion RNA editing in trypanosome mitochondria: characterization of RET2 functional domains by mutational analysis.Journal of molecular biology · 2010Article
- Mechanism of U insertion RNA editing in trypanosome mitochondria: the bimodal TUTase activity of the core complex.Journal of molecular biology · 2010Article
- Structure of the mitochondrial editosome-like complex associated TUTase 1 reveals divergent mechanisms of UTP selection and domain organization.Journal of molecular biology · 2010Article
- Novel TUTase associates with an editosome-like complex in mitochondria of Trypanosoma brucei.RNA (New York, N.Y.) · 2009Article
- Structure of a mitochondrial ribosome with minimal RNA.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Identification and characterization of nuclear non-canonical poly(A) polymerases from Trypanosoma brucei.Molecular and biochemical parasitology · 2009Article
- Guide RNA-binding complex from mitochondria of trypanosomatids.Molecular cell · 2008Article
- Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes.Genome research · 2008Article
- Uridine insertion/deletion editing in trypanosomes: a playground for RNA-guided information transfer.Wiley interdisciplinary reviews. RNAReview
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2 authors.
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Abstract
Terminal RNA uridylyltransferases (TUTases) are functionally and structurally diverse nucleotidyl transferases that catalyze template-independent 3' uridylylation of RNAs. Within the DNA polymerase beta-type superfamily, TUTases are closely related to non-canonical poly(A) polymerases. Studies of U-insertion/deletion RNA editing in mitochondria of trypanosomatids identified the first TUTase proteins and their cellular functions: post-transcriptional uridylylation of guide RNAs by RNA editing TUTase 1 (RET1) and U-insertion mRNA editing by RNA editing TUTase 2 (RET2). The editing TUTases possess conserved catalytic and nucleotide base recognition domains, yet differ in quaternary structure, substrate specificity and processivity. The cytosolic TUTases TUT3 and TUT4 have also been identified in trypanosomes but their biological roles remain to be established. Structural analyses have revealed a mechanism of cognate nucleoside triphosphate selection by TUTases, which includes protein-UTP contacts as well as contribution of the RNA substrate. This review focuses on biological functions and structures of trypanosomal TUTases.
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