Evidence map›Paper›PMID 18191645›Full record

Trial reportFree radical biology & medicine2008

Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome.

Sridevi Devaraj, Scott Leonard, Maret G Traber, Ishwarlal Jialal

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Free radical biology & medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01369043 (Modulation of Insulin and Exercise Responses by Vitamin E and Vitamin C), which is not on this map. Cited by 78 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 6 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01369043 naterminatednot on this mapstarted 2011, after this paper: background citation

Modulation of Insulin and Exercise Responses by Vitamin E and Vitamin C

TypeinterventionalSponsorUSDA Grand Forks Human Nutrition Research CenterRan2011 to 2012Enrolled1ConditionsExercise and Non-exercise Effect Upon Vitamins E and CArmsVitamin E and Vitamin C
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 6 syntheses or guidelines pooled it, 211 citations in OpenAlex.

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  16. Serum vitamin E concentrations and recovery of physical function during the year after hip fracture.The journals of gerontology. Series A, Biological sciences and medical sciences · 2011
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sridevi DevarajLaboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA 95817, USA. sridevi.devaraj@ucdmc.ucdavis.edu
Scott Leonard
Maret G Traber
Ishwarlal Jialal
Oregon State University · USUniversity of California Davis Medical Center · US

Funding

CLINICAL STUDIES IN NUTRITION AND METABOLISMK24AT000596 · NCCIH · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI JIALAL, ISHWARLAL · 2000 to 2009
$1.3M
Alpha-Tocopherol Modulation of Xenobiotic MetabolismR01DK067930 · NIDDK · OREGON STATE UNIVERSITY · PI TRABER, MARET G · 2006 to 2009
$1.2M
High Dose Alpha Tocopherol and Carotid AtherosclerosisR01AT000005 · NCCIH · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI JIALAL, ISHWARLAL · 1999 to 2004
$917k
NCCIH NIH HHS K24 AT000596NCCIH NIH HHS K24AT00596NCCIH NIH HHS R01 AT000005NCCIH NIH HHS R01AT00005NIDDK NIH HHS DK067930NIDDK NIH HHS R01 DK067930
6 · The paper itself

Abstract

Metabolic syndrome (MetS) is associated with increased incidence of diabetes and cardiovascular disease (CVD). Prospective clinical trials with alpha-tocopherol (AT) have not yielded positive results. Because AT supplementation decreases circulating gamma-tocopherol (GT), we evaluated supplementation with GT (800 mg/day), AT (800 mg/day), the combination or placebo for 6 weeks alone AT and GT concentrations, biomarkers of oxidative stress, and inflammation in subjects with MetS (n=20/group). Plasma AT and GT levels increased following supplementation with AT alone or GT alone or in combination. AT supplementation significantly decreased GT levels. Urinary alpha- and gamma-CEHC, metabolites of the respective Ts, also increased correspondingly, i.e., alpha-CEHC with AT and gamma-CEHC with GT supplementation, compared to placebo. HsCRP levels significantly decreased in the combined AT+GT group. LPS-activated whole blood release of IL-1 and IL-6 did not change. There was a significant decrease in TNF with AT alone or in combination with GT. Plasma MDA/HNE and lipid peroxides were significantly decreased with AT, GT, or in combination. Nitrotyrosine levels were significantly decreased only with GT or GT+AT but not with AT compared to placebo. Thus, the combination of AT and GT supplementation appears to be superior to either supplementation alone on biomarkers of oxidative stress and inflammation and needs to be tested in prospective clinical trials to elucidate its utility in CVD prevention.

Indexed as

Aldehydesalpha-TocopherolBiomarkersC-Reactive ProteinDietary SupplementsDouble-Blind MethodEnzyme-Linked Immunosorbent AssayFemalegamma-TocopherolHumansInflammationInterleukin-1Interleukin-6Lipid PeroxidesMaleMalondialdehydeAldehydesalpha-TocopherolBiomarkersC-Reactive Proteingamma-TocopherolInterleukin-1Interleukin-6Lipid PeroxidesMalondialdehydePlacebostert-4-hydroxy-2-nonenalTumor Necrosis Factor-alphaVitamins

Identifiers

PMID18191645
PMCPMC2676174
OpenAlexW2061440677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.