ArticleAmerican journal of ophthalmology2008
Vision function in HIV-infected individuals without retinitis: report of the Studies of Ocular Complications of AIDS Research Group.
Article in American journal of ophthalmology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000168 (Studies of Ocular Complications of AIDS), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Studies of Ocular Complications of AIDS (SOCA)
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Optical coherence tomography angiography measurements in patients with HIV: a systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Pooled it
- Optic nerve head morphology and visual field function in patients with AIDS and without infectious retinitis.Ocular immunology and inflammation · 2012Trial
- Article
- The integrity of psychophysical visual function in non-immunocompromised PLHIV (NIPLHIV) without retinitis on antiretroviral therapy (ART).African health sciences · 2023Article
- Significant loss of retinal nerve fibre layer and contrast sensitivity in people with well controlled HIV disease: implications for aging with HIV.Frontiers in ophthalmology · 2023Article
- Human immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy - An update.Indian journal of ophthalmology · 2020Review
- Retinal nerve fiber layer changes based on historic CD4 nadir among HIV positive patients undergoing glaucoma evaluation.International journal of ophthalmology · 2019Article
- Ophthalmologic Disease in HIV Infection: Recent Changes in Pathophysiology and Treatment.Current infectious disease reports · 2017Review
- Study of Retinal Nerve Fibre Layer Thickness and Visual Contrast Sensitivity in HIV Positive Individuals.Journal of clinical and diagnostic research : JCDR · 2017Article
- Relationship between Human Immunodeficiency Virus Neuroretinal Disorder and Vision-Specific Quality of Life among People with AIDS.Ophthalmology · 2015Observational
- Incidence and long-term outcomes of the human immunodefıciency virus neuroretinal disorder in patients with AIDS.Ophthalmology · 2015Observational
- Retinal Nerve Fiber and Optic Disc Morphology in Patients with Human Immunodeficiency Virus Using the Heidelberg Retina Tomography 3.PloS one · 2015Article
- Article
- HIV-1 impairs human retinal pigment epithelial barrier function: possible association with the pathogenesis of HIV-associated retinopathy.Laboratory investigation; a journal of technical methods and pathology · 2014Article
- Visual function assessment in simulated real-life situations in HIV-infected subjects.PloS one · 2014Article
- Evaluation of hepatitis C virus as a risk factor for HIV-associated neuroretinal disorder.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
- Retinal nerve fibre layer thickness and contrast sensitivity in HIV-infected individuals in South Africa: a case-control study.PloS one · 2013Article
- Association between retinal nerve fiber layer thickness and abnormalities of vision in people with human immunodeficiency virus infection.American journal of ophthalmology · 2012Article
- Retinal vessel caliber among people with acquired immunodeficiency syndrome: relationships with visual function.American journal of ophthalmology · 2012Article
- Human immunodeficiency virus and its effects on the visual system.Infectious disease reports · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
purposeTo evaluate the prevalence and risk factors for vision loss in patients with clinical or immunologic AIDS without infectious retinitis.
designA prospective, multicenter cohort study of patients with AIDS.
methodsOne thousand three hundred and fifty-one patients (2,671 eyes) at 19 clinical trials centers diagnosed with AIDS but without major ocular complications of HIV. Standardized measurements of visual acuity, automated perimetry, and contrast sensitivity were analyzed and correlated with measurements of patients' health and medical data relating to HIV infection. We evaluated correlations between vision function testing and HIV-related risk factors and medical testing.
resultsThere were significant (P<.05) associations between measures of decreasing vision function and indices of increasing disease severity, including Karnofsky score and hemoglobin. A significant relationship was seen between low-contrast sensitivity and decreasing levels of CD4+ T-cell count. Three percent of eyes had a visual acuity worse than 20/40 Snellen equivalents, which was significantly associated with a history of opportunistic infections and low Karnofsky score. When compared with external groups with normal vision, 39% of eyes had abnormal mean deviation on automated perimetry, 33% had abnormal pattern standard deviation, and 12% of eyes had low contrast sensitivity.
conclusionsThis study confirms that visual dysfunction is common in patients with AIDS but without retinitis. The most prevalent visual dysfunction is loss of visual field; nearly 40% of patients have some abnormal visual field. There is an association between general disease severity and less access to care and vision loss. The pathophysiology of this vision loss is unknown but is consistent with retinovascular disease or optic nerve disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.