Evidence map›Paper›PMID 18190707›Full record

ArticleGenome biology2008

Automated eukaryotic gene structure annotation using EVidenceModeler and the Program to Assemble Spliced Alignments.

Brian J Haas, Steven L Salzberg, Wei Zhu, Mihaela Pertea, Jonathan E Allen, Joshua Orvis, Owen White, C Robin Buell, Jennifer R Wortman

Abstract read
In one paragraph

Article in Genome biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2,527 papers.

0numbers the graph read from it
0cells of the map it votes in
2,527citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2,527 citing papers in PubMed.

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2,467 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Brian J HaasJ Craig Venter Institute, The Institute for Genomic Research, Rockville, Maryland 20850, USA. bhaas@broad.mit.edu
Steven L Salzberg
Wei Zhu
Mihaela Pertea
Jonathan E Allen
Joshua Orvis
Owen White
C Robin Buell
Jennifer R Wortman

Funding

COMPUTATIONAL MODELING OF GENES AND GENE STRUCTURER01LM006845 · NLM · UNIV OF MARYLAND, COLLEGE PARK · PI SALZBERG, STEVEN L. · 1999 to 2010
$5.9M
Bioinformatics Software for Analyzing Microbial GenomesR01GM083873 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI SALZBERG, STEVEN L. · 2008 to 2017
$2.1M
NIGMS NIH HHS R01 GM083873NLM NIH HHS R01 LM006845NLM NIH HHS R01-LM006845
6 · The paper itself

Abstract

EVidenceModeler (EVM) is presented as an automated eukaryotic gene structure annotation tool that reports eukaryotic gene structures as a weighted consensus of all available evidence. EVM, when combined with the Program to Assemble Spliced Alignments (PASA), yields a comprehensive, configurable annotation system that predicts protein-coding genes and alternatively spliced isoforms. Our experiments on both rice and human genome sequences demonstrate that EVM produces automated gene structure annotation approaching the quality of manual curation.

Indexed as

Gene ComponentsComputational BiologyDatabases, GeneticEukaryotaGenome, HumanGenome, PlantHumansOryzaProtein IsoformsSoftwareProtein Isoforms

Identifiers

PMID18190707
PMCPMC2395244

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.