ArticleMalaria journal2008
Differential evolution of anti-VAR2CSA- IgG3 in primigravidae and multigravidae pregnant women infected by Plasmodium falciparum.
Article in Malaria journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Pregnancy-specific malarial immunity and risk of malaria in pregnancy and adverse birth outcomes: a systematic review.BMC medicine · 2020Pooled it
- Kinetics of B cell responses to Plasmodium falciparum erythrocyte membrane protein 1 in Ghanaian women naturally exposed to malaria parasites.Journal of immunology (Baltimore, Md. : 1950) · 2014Trial
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- Article
- Impact of Hemoglobin S Trait on Cell Surface Antibody Recognition ofOpen forum infectious diseases · 2019Article
- IgM and IgG against Plasmodium falciparum lysate as surrogates of malaria exposure and protection during pregnancy.Malaria journal · 2018Article
- Comparison of the specificity of antibodies to VAR2CSA in Cameroonian multigravidae with and without placental malaria: a retrospective case-control study.Malaria journal · 2015Article
- Structure of the DBL3X-DBL4ε region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions.Scientific reports · 2015Article
- Sero-epidemiological evaluation of Plasmodium falciparum malaria in Senegal.Malaria journal · 2015Article
- Malaria and immunity during pregnancy and postpartum: a tale of two species.Parasitology · 2015Review
- Parity-dependent recognition of DBL1X-3X suggests an important role of the VAR2CSA high-affinity CSA-binding region in the development of the humoral response against placental malaria.Infection and immunity · 2015Article
- Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin.Emerging infectious diseases · 2015Article
- Antigen reversal identifies targets of opsonizing IgGs against pregnancy-associated malaria.Infection and immunity · 2014Article
- B-cell responses to pregnancy-restricted and -unrestricted Plasmodium falciparum erythrocyte membrane protein 1 antigens in Ghanaian women naturally exposed to malaria parasites.Infection and immunity · 2014Article
- High avidity antibodies to full-length VAR2CSA correlate with absence of placental malaria.PloS one · 2012Article
- Plasmodium falciparum population dynamics in a cohort of pregnant women in Senegal.Malaria journal · 2010Article
- Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPregnant women develop protective anti-VSA IgG1 and IgG3 when infected by Plasmodium falciparum. The major target of IgG from serum of infected pregnant women is VAR2CSA.
methodsIn this study, ELISA was used to compare the level of VAR2CSA DBL5epsilon- specific IgG subclasses at enrolment and at delivery in a cohort of pregnant women in Senegal. All antibody measures were analysed in relation to placental infection according to parity.
resultsThe results show an interaction between immune response to placental malaria and parity. A higher level of anti- DBL5epsilon- IgG3 at enrolment and a higher increase between enrolment and delivery were found in primigravidae who presented with uninfected placenta at delivery in comparison to those who presented with an infection of the placenta. However, high antibody level at delivery was associated with the infection of the placenta in multigravidae.
conclusionThis high level of IgG3 in uninfected primigravidae suggests a protective role of these antibodies in this susceptible group, highlighting the importance of VAR2CSA in general and of some of its variants still to be defined, in the induction of protective immunity to pregnancy malaria.
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