ArticleClinical and experimental immunology2008
Factors associated with CD4 lymphocyte counts in HIV-negative Senegalese individuals.
Article in Clinical and experimental immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Impact of menopausal status on human papillomavirus detection and cervical neoplasia in middle-aged Senegalese women.PloS one · 2026Article
- A Multistate Continuous Time-Inhomogeneous Markov Model for Assessing the CD4 Count Dynamics of HIV/AIDS Patients Undergoing Antiretroviral Therapy in KwaZulu-Natal, South Africa.International journal of environmental research and public health · 2025Article
- Reference intervals for CD4 and hemoglobin among apparently healthy pregnant women in Addis Ababa, Ethiopia.BMC research notes · 2025Article
- Determine Complete Blood Count Reference Values Among Healthy Adult Populations.Journal of blood medicine · 2024Article
- Per-pathogen virulence of HIV-1 subtypes A, C and D.Proceedings. Biological sciences · 2023Article
- Why does age at HIV infection correlate with set point viral load? An evolutionary hypothesis.Epidemics · 2022Article
- Factors related to baseline CD4 cell counts in HIV/AIDS patients: comparison of poisson, generalized poisson and negative binomial regression models.BMC research notes · 2021Article
- Socio-Demographic, Economic and Clinical Predictors for HAART Adherence Competence in HIV-Positive Adults at Felege Hiwot Teaching and Specialized Hospital, North West Ethiopia.HIV/AIDS (Auckland, N.Z.) · 2021Article
- Association between CD4 T cell counts and the immune status among adult critically ill HIV-negative patients in intensive care units in Uganda.AAS open research · 2019Article
- A portable optical reader and wall projector towards enumeration of bio-conjugated beads or cells.PloS one · 2017Article
- CD4 Cell Count: Declining Value for Antiretroviral Therapy Eligibility.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- T cell subset profile in healthy Zambian adults at the University Teaching Hospital.The Pan African medical journal · 2016Article
- Article
- Emotional, physical and financial burdens of stigma against people living with HIV/AIDS in China.AIDS care · 2016Article
- Establishment of Normal Reference Intervals for CD3(+), CD4(+), CD8(+), and CD4(+) to CD8(+) Ratio of T Lymphocytes in HIV Negative Adults from University of Gondar Hospital, North West Ethiopia.AIDS research and treatment · 2014Article
- Antiretroviral treatment outcomes amongst older adults in a large multicentre cohort in South Africa.PloS one · 2014Article
- Population specific reference ranges of CD3, CD4 and CD8 lymphocyte subsets among healthy Kenyans.AIDS research and therapy · 2013Article
- Women experience a better long-term immune recovery and a better survival on HAART in Lao People's Democratic Republic.BMC infectious diseases · 2013Article
- Population-based CD4 counts in a rural area in South Africa with high HIV prevalence and high antiretroviral treatment coverage.PloS one · 2013Article
- Gender differences in notification rates, clinical forms and treatment outcome of tuberculosis patients under the RNTCP.Lung India : official organ of Indian Chest Society · 2012Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
Abstract
CD4+ lymphocytes are a primary target of the human immunodeficiency virus (HIV), and CD4 counts are one of the factors used to measure disease progression in HIV-positive individuals. CD4 counts vary in uninfected individuals and across populations due to a variety of demographic, environmental, immunological and genetic factors that probably persist throughout the course of HIV infection. This study sought to determine reference levels and identify factors that influence lymphocyte counts in 681 HIV-uninfected adults in Senegal, where residents are exposed to a variety of infectious diseases and other conditions that may affect CD4 counts. Lymphocyte counts were assessed in commercial sex workers, symptomatic men and women presenting to the University of Dakar infectious disease clinic for out-patient care and women seeking family planning services. CD4 and CD3 lymphocyte counts differed between the four study groups (P < 0.01). Men had the lowest mean CD4 count (711.6 cells/microl), while commercial sex workers had the highest levels (966.0 cells/microl). After adjustment for age and other behavioural and clinical factors, the difference in CD4 counts between the three groups of women did not remain. However, both gender and smoking were associated independently with CD4 counts, as men maintained lower mean CD4 counts (beta = -156.4 cells/microl, P < 0.01) and smokers had higher mean CD4 counts (beta = 124.0 cells/microl, P < 0.01) than non-smokers in multivariable analyses. This study is the first to explore factors that may influence CD4 levels in Senegal and to estimate baseline CD4 levels among HIV-negatives, information that may guide clinicians in interpreting CD4 counts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.