ArticleBJOG : an international journal of obstetrics and gynaecology2008
Selective single blastocyst transfer reduces the multiple pregnancy rate and increases pregnancy rates: a pre- and postintervention study.
Article in BJOG : an international journal of obstetrics and gynaecology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02988544 (Artificial Shrinkage of Fresh Blastocyst), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Artificial Shrinkage of Fresh Blastocyst: Impact on Success Rates in Assisted Reproductive Technology
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Number of embryos for transfer following in vitro fertilisation or intra-cytoplasmic sperm injection.The Cochrane database of systematic reviews · 2020Pooled it
- Number of embryos for transfer following in vitro fertilisation or intra-cytoplasmic sperm injection.The Cochrane database of systematic reviews · 2013Pooled it
- Embryo selection at the cleavage stage using Raman spectroscopy of day 3 culture medium and machine learning: a preliminary study.Frontiers in endocrinology · 2025Article
- Effects of patient education on desire for twins and use of elective single embryo transfer procedures during ART treatment: A systematic review.Reproductive biomedicine & society online · 2018Review
- Association Between Progesterone Elevation on the Day of Human Chronic Gonadotropin Trigger and Pregnancy Outcomes After Fresh Embryo Transfer inFrontiers in endocrinology · 2018Review
- Public health implications of a North American publicly funded in vitro fertilization program; lessons to learn.Journal of assisted reproduction and genetics · 2015Article
- Review
- Maternal age and intracytoplasmic sperm injection outcome in infertile couples at Khartoum, Sudan.F1000Research · 2015Article
- Assisted Reproductive Technologies (ART) with baboons generate live offspring: a nonhuman primate model for ART and reproductive sciences.Reproductive sciences (Thousand Oaks, Calif.) · 2010Article
- Deep phenotyping to predict live birth outcomes in in vitro fertilization.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Revisiting oocyte-somatic cell interactions: in search of novel intrafollicular predictors and regulators of oocyte developmental competence.Molecular human reproduction · 2008Article
- Outcomes of Preimplantation Genetic Testing for Single Gene Defects in a Privately Funded Period and Publicly Funded Period: A North-American Single Center Experience.Journal of reproduction & infertilityArticle
- Clinical outcome of frozen blastocyst transfer; single vs. double transfer.Journal of assisted reproduction and geneticsArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the clinical pregnancy rate (CPR) and multiple pregnancy rate (MPR) in a large in vitro fertilisation (IVF) programme before and after the introduction of single blastocyst transfer (SBT) strategy in a selected group of women.
designA 3-year pre- and postintervention study.
settingA tertiary reproductive medicine and assisted conception unit in a London teaching hospital. POPULATION: Two thousand four hundred and fifty-one fresh IVF cycles performed between July 2004 and June 2007 at the Assisted Conception Unit at Guy's and St Thomas' Hospital NHS Foundation Trust were included in the study.
methodsIn January 2006, we implemented a multidisciplinary intervention involving the introduction of a selective day 5 SBT service together with an educational programme on the risks of multiple pregnancy and potential advantages of blastocyst transfer aimed at couples at high risk of multiple pregnancy.
main outcome measuresThe CPR per cycle started and MPR per clinical pregnancy achieved.
resultsA statistically significant increase in the CPR from 27% (324/1198) to 32% (395/1253) (risk difference [RD] 5%, risk ratio [RR] 1.17, 95% CI 1.03-1.32, P= 0.015) and reduction in the MPR per clinical pregnancy from 32% (103/272) to 17% (69/395) (RD 15%, RR 0.46, 95% CI 0.35-0.60, P < 0.001) were observed after introduction of the SBT service.
conclusionSelective SBT in women with good prognosis can reduce the MPR after IVF while maintaining the overall success rate of the IVF programme.
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