ReviewHeart failure reviews2008
The significance of brain aminopeptidases in the regulation of the actions of angiotensin peptides in the brain.
Review in Heart failure reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Brain AT1 and AT2 receptors and nitric oxide in baroreflex regulation of renal sympathetic activity in unanaesthetised rats.Scientific reports · 2025Article
- Spontaneous and evoked angiotensin II sniffer cell activity in the lamina terminalis in vitro.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- The role of peptidase neurolysin in neuroprotection and neural repair after stroke.Neural regeneration research · 2021Article
- Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice.Journal of neurochemistry · 2020Article
- Peptidase neurolysin is an endogenous cerebroprotective mechanism in acute neurodegenerative disorders.Medical hypotheses · 2019Article
- Mammalian Glutamyl Aminopeptidase Genes (ENPEP) and Proteins: Comparative Studies of a Major Contributor to Arterial Hypertension.Journal of data mining in genomics & proteomics · 2017Article
- A Role for the Brain RAS in Alzheimer's and Parkinson's Diseases.Frontiers in endocrinology · 2013Review
- The effects of para-chloromercuribenzoic acid and different oxidative and sulfhydryl agents on a novel, non-AT1, non-AT2 angiotensin binding site identified as neurolysin.Regulatory peptides · 2013Article
- Direct evidence for intrarenal chymase-dependent angiotensin II formation on the diabetic renal microvasculature.Hypertension (Dallas, Tex. : 1979) · 2013Article
- The brain renin-angiotensin system: a diversity of functions and implications for CNS diseases.Pflugers Archiv : European journal of physiology · 2013Review
- Distinct Molecular Effects of Angiotensin II and Angiotensin III in Rat Astrocytes.International journal of hypertension · 2013Article
- Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension.International journal of hypertension · 2012Article
- Distribution of a novel binding site for angiotensins II and III in mouse tissues.Regulatory peptides · 2010Article
- Preliminary biochemical characterization of the novel, non-AT1, non-AT2 angiotensin binding site from the rat brain.Endocrine · 2010Article
- Bioinformatic analysis of gene sets regulated by ligand-activated and dominant-negative peroxisome proliferator-activated receptor gamma in mouse aorta.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- Major role for ACE-independent intrarenal ANG II formation in type II diabetes.American journal of physiology. Renal physiology · 2010Article
- A map and new directions for the (pro)renin receptor in the brain: focus on "A role of the (pro)renin receptor in neuronal cell differentiation".American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- Angiotensin modulation of rostral ventrolateral medulla (RVLM) in cardiovascular regulation.Molecular and cellular endocrinology · 2009Review
- Human brain contains a novel non-AT1, non-AT2 binding site for active angiotensin peptides.Life sciences · 2008Article
- An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy.Physiology (Bethesda, Md.) · 2008Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
From the outset, the concept of a brain renin-angiotensin system (RAS) has been controversial and this controversy continues to this day. In addition to the unresolved questions as to the means by which, and location(s) where brain Ang II is synthesized, and the uncertainties regarding the functionality of the different subtypes of Ang II receptors in the brain, a new controversy has arisen with respect to the identity of the angiotensin peptide(s) that activate brain AT(1) receptors. While it has been known for some time that Ang III can activate Ang II receptors with equivalent or near-equivalent efficacy to Ang II, it has been proposed that in the brain, only Ang III is active. This proposal, which we have named "The Angiotensin III Hypothesis" states that Ang II must be converted to Ang III in order to activate brain AT(1) receptors. This review examines several aspects of the controversies regarding the brain RAS with a special focus on brain aminopeptidases, studies that either support or refute The Angiotensin III Hypothesis, and the implications of The Angiotensin III Hypothesis for the activity of the brain RAS. It also addresses the need for further research that can test The Angiotensin III Hypothesis and definitively identify the angiotensin peptide(s) that activate brain AT(1) receptor-mediated effects.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.