ArticleThe Journal of physiology2008
Effects of twin pregnancy and periconceptional undernutrition on maternal metabolism, fetal growth and glucose-insulin axis function in ovine pregnancy.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of Ramadan fasting during pregnancy on perinatal outcomes: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2018Pooled it
- Article
- Fetal Growth in Twin Pregnancies and the Choice of Growth Chart.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2022Article
- Effects of Melatonin Supplementation during Pregnancy on Reproductive Performance, Maternal-Placental-Fetal Redox Status, and Placental Mitochondrial Function in a Sow Model.Antioxidants (Basel, Switzerland) · 2021Article
- Promoting viable twin birth on single-bearing ewes in the Arabian Gulf region: reproductive, nutritional, and economic perspectives.Tropical animal health and production · 2021Review
- Developmental outcomes in small-for-gestational age twins using a singleton vs twin birthweight reference.American journal of obstetrics & gynecology MFM · 2021Article
- Simulated shift work disrupts maternal circadian rhythms and metabolism, and increases gestation length in sheep.The Journal of physiology · 2019Article
- Maternal Supplementation with Antioxidant Vitamins in Sheep Results in Increased Transfer to the Fetus and Improvement of Fetal Antioxidant Status and Development.Antioxidants (Basel, Switzerland) · 2019Article
- Hypoxia and Oxidative Stress Are Associated with Reduced Fetal Growth in Twin and Undernourished Sheep Pregnancies.Animals : an open access journal from MDPI · 2018Article
- Attenuation of ductus arteriosus intimal thickening in preterm sheep twins compared with singletons.The journal of physiological sciences : JPS · 2017Article
- Maternal undernutrition during the pre- and post-conception periods in twin-bearing hairsheep ewes: effects on fetal and placental development at mid-gestation.Tropical animal health and production · 2017Article
- Differential pathways to adult metabolic dysfunction following poor nutrition at two critical developmental periods in sheep.PloS one · 2014Article
- Epigenetic changes in fetal hypothalamic energy regulating pathways are associated with maternal undernutrition and twinning.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Timing of inter-generational prevention of adiposity and type 2 diabetes.The Journal of physiology · 2012Article
- Size at birth and adult fat mass in twin sheep are determined in early gestation.The Journal of physiology · 2012Article
- The effect of flushing and stimulus of estrogenized does on reproductive performance of anovulatory-range goats.Tropical animal health and production · 2011Article
- Characterization of glucose-insulin responsiveness and impact of fetal number and sex difference on insulin response in the sheep fetus.American journal of physiology. Endocrinology and metabolism · 2011Article
- Chronic exposure to elevated norepinephrine suppresses insulin secretion in fetal sheep with placental insufficiency and intrauterine growth restriction.American journal of physiology. Endocrinology and metabolism · 2010Article
- Increased risk of type 2 diabetes in elderly twins.Diabetes · 2009Article
- Periconceptional nutrition, twinning and how this impacts on current understanding of the aetiology and pathophysiology of the metabolic syndrome.The Journal of physiology · 2008Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although twins have lower birthweights than singletons, they may not experience the increased disease risk in adulthood reportedly associated with low birthweight. In contrast, another periconceptional event, maternal undernutrition, does not reduce birthweight but does affect fetal and postnatal physiology in sheep. We therefore studied maternal and fetal metabolism, growth and glucose-insulin axis function in late gestation in twin and singleton sheep pregnancies, either undernourished from 60 days before until 30 days after conception or fed ad libitum. We found that twin-bearing ewes had decreased maternal food intake in late gestation and lower maternal and fetal plasma glucose and insulin levels. Twin fetuses had fewer everted placentomes, grew slower in late gestation, and had a greater insulin response to a glucose challenge, but lesser response to arginine. In contrast, periconceptional undernutrition led to increased maternal food intake and a more rapid fall in maternal glucose levels in response to fasting. Periconceptional undernutrition increased the number of everted placentomes, and abolished the difference in insulin responses to glucose between twins and singletons. Thus, the physiology of twin pregnancy is quite different from that of singleton pregnancy, and is probably determined by a combination of factors acting in both early and late gestation. The inconsistency of the relationships between low birthweight and postnatal disease risk of twins may lie in their very different fetal development. These data suggest that twin pregnancy may be another paradigm of developmental programming, and indicate that twins and singletons must be examined separately in any study of fetal or postnatal physiology.
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