Trial reportThe British journal of general practice : the journal of the Royal College of General Practitioners2008
Poor adherence with inhaled corticosteroids for asthma: can using a single inhaler containing budesonide and formoterol help?
Trial report in The British journal of general practice : the journal of the Royal College of General Practitioners, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 13 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 13 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Comparative efficacy of inhalers in mild-to-moderate asthma: systematic review and network meta-analysis.Scientific reports · 2022Pooled it
- Pooled it
- Interventions to improve adherence to inhaled steroids for asthma.The Cochrane database of systematic reviews · 2017Pooled it
- Comparative effectiveness of long term drug treatment strategies to prevent asthma exacerbations: network meta-analysis.BMJ (Clinical research ed.) · 2014Pooled it
- Combination formoterol and budesonide as maintenance and reliever therapy versus combination inhaler maintenance for chronic asthma in adults and children.The Cochrane database of systematic reviews · 2013Pooled it
- Combination formoterol and budesonide as maintenance and reliever therapy versus current best practice (including inhaled steroid maintenance), for chronic asthma in adults and children.The Cochrane database of systematic reviews · 2013Pooled it
- Formoterol versus short-acting beta-agonists as relief medication for adults and children with asthma.The Cochrane database of systematic reviews · 2010Pooled it
- Addition of long-acting beta2-agonists to inhaled steroids versus higher dose inhaled steroids in adults and children with persistent asthma.The Cochrane database of systematic reviews · 2010Pooled it
- Addition of inhaled long-acting beta2-agonists to inhaled steroids as first line therapy for persistent asthma in steroid-naive adults and children.The Cochrane database of systematic reviews · 2009Pooled it
- Combination formoterol and budesonide as maintenance and reliever therapy versus inhaled steroid maintenance for chronic asthma in adults and children.The Cochrane database of systematic reviews · 2009Pooled it
- Combination formoterol and inhaled steroid versus beta2-agonist as relief medication for chronic asthma in adults and children.The Cochrane database of systematic reviews · 2009Pooled it
- Regular treatment with salmeterol for chronic asthma: serious adverse events.The Cochrane database of systematic reviews · 2008Pooled it
- Canadian Thoracic Society 2012 guideline update: diagnosis and management of asthma in preschoolers, children and adults.Canadian respiratory journalGuideline
- Fixed or adjustable maintenance-dose budesonide/formoterol compared with fixed maintenance-dose salmeterol/fluticasone propionate in asthma patients aged >or=16 years: post hoc analysis of a randomized, double-blind/open-label extension, parallel-group study.Clinical drug investigation · 2010Trial
- Single maintenance and reliever therapy strategies for Implementation and effectiveness trial (SMART & SIMPLE Trial): study protocol for a type II hybrid effectiveness-implementation cluster-randomized controlled trial.Contemporary clinical trials communications · 2026Article
- Adoption and implementation of maintenance and reliever therapy for adults with moderate-to-severe asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Article
- Article
- Clinical remission with biologic therapies in severe asthma: a matter of definition.The European respiratory journal · 2024Article
- An Analysis of Medication Adherence in a Large Outpatient Population During the COVID-19 Pandemic Using a Novel Value-Based Pharmacy System.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2024Article
- "As-Needed" Inhaled Corticosteroids for Patients With Asthma.The journal of allergy and clinical immunology. In practice · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPoor adherence with inhaled corticosteroids is an important problem in asthma management. Previous approaches to improving adherence have had limited success.
aimTo determine whether treatment with a single inhaler containing a long-acting beta(2)-agonist and a corticosteroid for maintenance treatment and symptom relief can overcome the problem of poor adherence with inhaled corticosteroids. DESIGN OF STUDY: Randomised, parallel group, open-label trial.
settingForty-four general practices in Nottinghamshire.
methodParticipants who used less than 70% of their prescribed dose of inhaled corticosteroid and had poorly controlled asthma were randomised to budesonide 200 microg one puff twice daily plus their own short-acting beta(2)-agonist as required (control group), or budesonide/formoterol 200/6 microg one puff once daily and as required (active group) for 6 months. The primary outcome was inhaled corticosteroid dose.
resultsSeventy-one participants (35 control, 36 active group) were randomised. Adherence with budesonide in the control group was approximately 60% of the prescribed dose. Participants in the active group used approximately 80% more budesonide than participants in the control group (448 versus 252 microg/day, mean difference 196 mug, 95% confidence interval 113 to 279; P<0.001) and were less likely to withdraw from the study (3 versus 13; P<0.01). No safety issues were identified.
conclusionUsing a single inhaler for both maintenance treatment and symptom relief approximately doubled the dose of inhaled corticosteroid taken, suggesting this could be a useful strategy to overcome the problems related to poor adherence with inhaled corticosteroids.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.