ArticleBMC genomics2008
Profiling expression changes caused by a segmental aneuploid in maize.
Article in BMC genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 59 citations in OpenAlex.
- Effect of heterozygous deletions on phenotypic changes and dosage compensation in Arabidopsis thaliana.Scientific reports · 2025Article
- Genome-Wide Expression Analysis of Long Noncoding RNAs and Their Target Genes in MetafemaleInternational journal of molecular sciences · 2023Article
- Genome-Wide Effects on Gene Expression Between Parental and Filial Generations of Trisomy 11 and 12 of Rice.Rice (New York, N.Y.) · 2023Article
- Anther Culture-Derived Haploids ofPlants (Basel, Switzerland) · 2022Article
- Detection of ploidy and chromosomal aberrations in commercial oil palm using high-throughput SNP markers.Planta · 2021Article
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- Cellular Stress Associated with Aneuploidy.Developmental cell · 2018Review
- Global Analysis of Gene Expression in Response to Whole-Chromosome Aneuploidy in Hexaploid Wheat.Plant physiology · 2017Article
- Genes and Small RNA Transcripts Exhibit Dosage-Dependent Expression Pattern in Maize Copy-Number Alterations.Genetics · 2016Article
- Genome-wide construction of a series of designed segmental aneuploids in Saccharomyces cerevisiae.Scientific reports · 2015Article
- Sprouty gene dosage influences temporal-spatial dynamics of primary enamel knot formation.BMC developmental biology · 2015Article
- Genome-wide identification of housekeeping genes in maize.Plant molecular biology · 2014Article
- Facts and artifacts in studies of gene expression in aneuploids and sex chromosomes.Chromosoma · 2014Review
- Buffering and proteolysis are induced by segmental monosomy in Drosophila melanogaster.Nucleic acids research · 2012Article
- Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells.Molecular systems biology · 2012Article
- Transcriptional robustness and protein interactions are associated in yeast.BMC systems biology · 2011Article
- Article
- Article
- Genomic responses to abnormal gene dosage: the X chromosome improved on a common strategy.PLoS biology · 2010Article
- Aneuploidy causes tissue-specific qualitative changes in global gene expression patterns in maize.Plant physiology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile changes in chromosome number that result in aneuploidy are associated with phenotypic consequences such as Down syndrome and cancer, the molecular causes of specific phenotypes and genome-wide expression changes that occur in aneuploids are still being elucidated.
resultsWe employed a segmental aneuploid condition in maize to study phenotypic and gene expression changes associated with aneuploidy. Maize plants that are trisomic for 90% of the short arm of chromosome 5 and monosomic for a small distal portion of the short arm of chromosome 6 exhibited a phenotypic syndrome that includes reduced stature, tassel morphology changes and the presence of knots on the leaves. The knotted-like homeobox gene knox10, which is located on the short arm of chromosome 5, was shown to be ectopically expressed in developing leaves of the aneuploid plants. Expression profiling revealed that approximately 40% of the expressed genes in the trisomic region exhibited the expected 1.5 fold increased transcript levels while the remaining 60% of genes did not show altered expression even with increased gene dosage.
conclusionWe found that the majority of genes with altered expression levels were located within the chromosomal regions affected by the segmental aneuploidy and exhibits dosage-dependent expression changes. A small number of genes exhibit higher levels of expression change not predicted by the dosage, or display altered expression even though they are not located in the aneuploid regions.
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