ArticleWorld journal of gastroenterology2008
Methylation of TIMP3 in esophageal squamous cell carcinoma.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases.International journal of molecular sciences · 2020Review
- MAb NJ001 inhibits lung adenocarcinoma invasiveness by directly regulating TIMP-3 promoter activity via FOXP1 binding sites.Thoracic cancer · 2020Article
- Article
- The Clinical Utility of TIMP3 Expression in ACTH-Secreting Pituitary Tumor.Journal of molecular neuroscience : MN · 2016Article
- Decreased astroglial monocarboxylate transporter 4 expression in temporal lobe epilepsy.Molecular neurobiology · 2014Article
- Review of the alterations in DNA methylation in esophageal squamous cell carcinoma.Surgery today · 2013Review
- Identification of unique expression signatures and therapeutic targets in esophageal squamous cell carcinoma.BMC research notes · 2012Article
- DNA methylation in promoter region as biomarkers in prostate cancer.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Promoter hypermethylation in prostate cancer.Cancer control : journal of the Moffitt Cancer Center · 2010Review
- Quantitation of DNA methylation by melt curve analysis.BMC cancer · 2009Article
- Article
- Similarity of aberrant DNA methylation in Barrett's esophagus and esophageal adenocarcinoma.Molecular cancer · 2008Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo measure the frequency of DNA methylation of the tissue inhibitor of metalloproteinase 3 (TIMP3) promoter and relate this to any change of gene expression in esophageal squamous cell carcinoma in patients from a region of high incidence in China.
methodsCancer cell lines were treated with or without the demethylating reagent 5-aza-2'-deoxycytidine. Methylation of the TIMP3 promoter was assessed in three regions by melt curve analysis and its expression was assessed by real-time RT-PCR. Tumors and proximal resection margins were obtained from 64 patients with esophageal squamous cell carcinoma from a region of high incidence in China. Methylation was assessed by melt curve analysis and expression by immunohistochemistry.
resultsMethylation in one of the three promoter regions assessed correlated with gene silencing in esophageal cell lines. A degree of methylation of TIMP3 was found in only four esophageal squamous cell carcinomas, and partial loss of TIMP3 protein expression in just one.
conclusionMethylation and loss of expression of TIMP3 occurs infrequently in esophageal squamous cell carcinoma in a region of high incidence in China.
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