ReviewNMR in biomedicine2008
MRI in ocular drug delivery.
Review in NMR in biomedicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Medical Imaging Technology and Imaging Agents.Advances in experimental medicine and biology · 2023Article
- Monitoring New Long-Lasting Intravitreal Formulation for Glaucoma with Vitreous Images Using Optical Coherence Tomography.Pharmaceutics · 2021Article
- Transscleral Iontophoresis for Noninvasive Ocular Drug Delivery of Macromolecules.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2020Article
- Ocular Biodistribution Studies using Molecular Imaging.Pharmaceutics · 2019Review
- Diffusive Transport in the Vitreous Humor: Experimental and Analytical Studies.Journal of heat transfer · 2019Review
- Imaging Techniques in the Diagnosis and Management of Ocular Tumors: Prospects and Challenges.The AAPS journal · 2018Review
- Ultrahigh field MR imaging of a subconjunctival anti-glaucoma drug delivery system in a rabbit model.Scientific reports · 2017Article
- Ocular delivery of pRNA nanoparticles: distribution and clearance after subconjunctival injection.Pharmaceutical research · 2014Article
- MRI study of subconjunctival and intravitreal injections.Journal of pharmaceutical sciences · 2012Article
- Breakdown of the blood-ocular barrier as a strategy for the systemic use of nanosystems.Pharmaceutics · 2012Article
- Review: magnetic resonance imaging techniques in ophthalmology.Molecular vision · 2012Review
- Ocular pharmacokinetic study using T₁ mapping and Gd-chelate- labeled polymers.Pharmaceutical research · 2011Article
- In vivo ocular fluorophotometry: delivery of fluoresceinated dextrans via transscleral diffusion in rabbits.Investigative ophthalmology & visual science · 2011Article
- Mass spectrometry in ocular drug research.Mass spectrometry reviewsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Conventional pharmacokinetic methods for studying ocular drug delivery are invasive and cannot be conveniently applied to humans. The advancement of MRI technology has provided new opportunities in ocular drug-delivery research. MRI provides a means to non-invasively and continuously monitor ocular drug-delivery systems with a contrast agent or compound labeled with a contrast agent. It is a useful technique in pharmacokinetic studies, evaluation of drug-delivery methods, and drug-delivery device testing. Although the current status of the technology presents some major challenges to pharmaceutical research using MRI, it has a lot of potential. In the past decade, MRI has been used to examine ocular drug delivery via the subconjunctival route, intravitreal injection, intrascleral injection to the suprachoroidal space, episcleral and intravitreal implants, periocular injections, and ocular iontophoresis. In this review, the advantages and limitations of MRI in the study of ocular drug delivery are discussed. Different MR contrast agents and MRI techniques for ocular drug-delivery research are compared. Ocular drug-delivery studies using MRI are reviewed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.