ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2007
Sex determination in platypus and echidna: autosomal location of SOX3 confirms the absence of SRY from monotremes.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 72 citations in OpenAlex.
- AMHY and sex determination in egg-laying mammals.Genome biology · 2025Article
- Sex chromosome degeneration, turnover, and sex-biased expression of sex-linked transcripts in African clawed frogs (Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Review
- The evolutionary process of mammalian sex determination genes focusing on marsupial SRYs.BMC evolutionary biology · 2018Article
- Exchange of genetic information between therian X and Y chromosome gametologs in old evolutionary strata.Ecology and evolution · 2017Article
- Brain Sexual Differentiation and Requirement of SRY: Why or Why Not?Frontiers in neuroscience · 2017Review
- Sequential Turnovers of Sex Chromosomes in African Clawed Frogs (G3 (Bethesda, Md.) · 2016Article
- Did sex chromosome turnover promote divergence of the major mammal groups?: De novo sex chromosomes and drastic rearrangements may have posed reproductive barriers between monotremes, marsupials and placental mammals.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Review
- Evolution of vertebrate sex chromosomes and dosage compensation.Nature reviews. Genetics · 2016Review
- Weird mammals provide insights into the evolution of mammalian sex chromosomes and dosage compensation.Journal of genetics · 2015Review
- No evidence for a second evolutionary stratum during the early evolution of mammalian sex chromosomes.PloS one · 2012Article
- Identification of mediator complex 26 (Crsp7) gametologs on platypus X1 and Y5 sex chromosomes: a candidate testis-determining gene in monotremes?Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- Recent advances in X-chromosome inactivation.Journal of cellular physiology · 2011Review
- Sex reversal in zebrafish fancl mutants is caused by Tp53-mediated germ cell apoptosis.PLoS genetics · 2010Article
- Evolution and survival on eutherian sex chromosomes.PLoS genetics · 2009Article
- Turnover of sex chromosomes in the stickleback fishes (gasterosteidae).PLoS genetics · 2009Article
- Enrichment of brain-related genes on the mammalian X chromosome is ancient and predates the divergence of synapsid and sauropsid lineages.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
- The chicken (Gallus gallus) Z chromosome contains at least three nonlinear evolutionary strata.Genetics · 2008Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
In eutherian ('placental') mammals, sex is determined by the presence or absence of the Y chromosome-borne gene SRY, which triggers testis determination. Marsupials also have a Y-borne SRY gene, implying that this mechanism is ancestral to therians, the SRY gene having diverged from its X-borne homologue SOX3 at least 180 million years ago. The rare exceptions have clearly lost and replaced the SRY mechanism recently. Other vertebrate classes have a variety of sex-determining mechanisms, but none shares the therian SRY-driven XX female:XY male system. In monotreme mammals (platypus and echidna), which branched from the therian lineage 210 million years ago, no orthologue of SRY has been found. In this study we show that its partner SOX3 is autosomal in platypus and echidna, mapping among human X chromosome orthologues to platypus chromosome 6, and to the homologous chromosome 16 in echidna. The autosomal localization of SOX3 in monotreme mammals, as well as non-mammal vertebrates, implies that SRY is absent in Prototheria and evolved later in the therian lineage 210-180 million years ago. Sex determination in platypus and echidna must therefore depend on another male-determining gene(s) on the Y chromosomes, or on the different dosage of a gene(s) on the X chromosomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.