ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- Current Progress on Central Cholinergic Receptors as Therapeutic Targets for Alzheimer's Disease.Current Alzheimer research · 2024Review
- Transgenic rodents as dynamic models for the study of respiratory rhythm generation and modulation: a scoping review and a bibliometric analysis.Frontiers in physiology · 2023Article
- Molecular characterization of frog vocal neurons using constellation pharmacology.Journal of neurophysiology · 2020Article
- Neuroanatomical Basis of State-Dependent Activity of Upper Airway Muscles.Frontiers in neurology · 2018Review
- Developmental nicotine exposure alters potassium currents in hypoglossal motoneurons of neonatal rat.Journal of neurophysiology · 2017Article
- Nicotinic receptor activation contrasts pathophysiological bursting and neurodegeneration evoked by glutamate uptake block on rat hypoglossal motoneurons.The Journal of physiology · 2016Article
- Developmental changes in the morphology of mouse hypoglossal motor neurons.Brain structure & function · 2016Article
- Cholinergic neurons in the mouse rostral ventrolateral medulla target sensory afferent areas.Brain structure & function · 2013Article
- Atropine microdialysis within or near the pre-Botzinger Complex increases breathing frequency more during wakefulness than during NREM sleep.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Atomic force microscopy to characterize binding properties of α7-containing nicotinic acetylcholine receptors on neurokinin-1 receptor-expressing medullary respiratory neurons.Experimental physiology · 2013Article
- Insights into the neurobiology of the nicotinic cholinergic system and nicotine addiction from mice expressing nicotinic receptors harboring gain-of-function mutations.Pharmacological reviews · 2012Review
- Cyclothiazide-induced persistent increase in respiratory-related activity in vitro.The Journal of physiology · 2012Article
- Tonic neuromodulation of the inspiratory rhythm generator.Frontiers in physiology · 2012Article
- Recent advances in gene manipulation and nicotinic acetylcholine receptor biology.Biochemical pharmacology · 2011Review
- Altered activity-rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the β2 nicotinic receptor.Molecular psychiatry · 2011Article
- Identification of a cholinergic modulatory and rhythmogenic mechanism within the lamprey respiratory network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Central CO2 chemoreception and integrated neural mechanisms of cardiovascular and respiratory control.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Review
- Prenatal nicotine exposure alters medullary nicotinic and AMPA-mediated control of respiratory frequency in vitro.Respiratory physiology & neurobiology · 2009Article
- Alterations in cholinergic sensitivity of respiratory neurons induced by pre-natal nicotine: a mechanism for respiratory dysfunction in neonatal mice.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Article
- Central cholinergic regulation of respiration: nicotinic receptors.Acta pharmacologica Sinica · 2009Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Acetylcholine and nicotine can modulate respiratory patterns by acting on nicotinic acetylcholine receptors (nAChRs) in the preBötzinger complex (preBötC). To further explore the molecular composition of these nAChRs, we studied a knock-in mouse strain with a leucine-to-alanine mutation in the M2 pore-lining region (L9'A) of the nAChR alpha4 subunit; this mutation renders alpha4-containing receptors hypersensitive to agonists. We recorded respiratory-related rhythmic motor activity from hypoglossal nerve (XIIn) and patch-clamped preBötC inspiratory neurons in an in vitro medullary slice preparation from neonatal mice. Nicotine affected respiratory rhythm at concentrations approximately 100-fold lower in the homozygous L9'A knock-in mice compared with wild-type mice. Bath application of 5 nm nicotine increased the excitability of preBötC inspiratory neurons, increased respiratory frequency, and induced tonic/seizure-like activities in XIIn in L9'A mice, effects similar to those induced by 1 microM nicotine in wild-type mice. In L9'A mice, microinjection of low nanomolar concentrations of nicotine into the preBötC increased respiratory frequency, whereas injection into the ipsilateral hypoglossal (XII) nucleus induced tonic/seizure-like activity. The alpha4*-selective nAChR antagonist dihydro-beta-erythroidine produced opposite effects and blocked the nicotinic responses. These data, showing that nAChRs in the preBötC and XII nucleus in L9'A mice are hypersensitive to nicotine and endogenous ACh, suggest that functional alpha4* nAChRs are present in the preBötC. They mediate cholinergic/nicotinic modulation of the excitability of preBötC inspiratory neurons and of respiratory rhythm. Furthermore, functional alpha4* nAChRs are present in XII nucleus and mediate cholinergic/nicotinic modulation of tonic activity in XIIn.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.