ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Effects of pH buffering on horizontal and ganglion cell light responses in primate retina: evidence for the proton hypothesis of surround formation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 101 citations in OpenAlex.
- Origin and functional impact of early nonlinearities in primate retina.bioRxiv : the preprint server for biology · 2026Article
- Rod photoreceptors control the ON vs OFF polarity of cone-signaling neurons.Communications biology · 2026Article
- Decoding the roles of bipolar, amacrine, and horizontal cells.Handbook of clinical neurology · 2026Review
- pH in the vertebrate retina and its naturally occurring and pathological changes.Progress in retinal and eye research · 2025Review
- Diversity of Ganglion Cell Responses to Saccade-Like Image Shifts in the Primate Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Time-Frequency Analysis of ERG With Discrete Wavelet Transform and Matching Pursuits for Glaucoma.Translational vision science & technology · 2022Article
- Classical center-surround receptive fields facilitate novel object detection in retinal bipolar cells.Nature communications · 2022Article
- Tandem pore domain acid-sensitive K channel 3 (TASK-3) regulates visual sensitivity in healthy and aging retina.Science advances · 2022Article
- Origins of direction selectivity in the primate retina.Nature communications · 2022Article
- A multiscale continuum model of the vertebrate outer retina: The temporal dynamics of background-induced flicker enhancement.Journal of theoretical biology · 2021Article
- Linear and nonlinear chromatic integration in the mouse retina.Nature communications · 2021Article
- Wide-field amacrine cell inputs to ON parasol ganglion cells in macaque retina.The Journal of comparative neurology · 2020Article
- Molecular mechanisms underlying selective synapse formation of vertebrate retinal photoreceptor cells.Cellular and molecular life sciences : CMLS · 2020Review
- Neuronal Glutamatergic Synaptic Clefts Alkalinize Rather Than Acidify during Neurotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Horizontal Cell Feedback to Cone Photoreceptors in Mammalian Retina: Novel Insights From the GABA-pH Hybrid Model.Frontiers in cellular neuroscience · 2020Review
- Diverse Cell Types, Circuits, and Mechanisms for Color Vision in the Vertebrate Retina.Physiological reviews · 2019Review
- Novel hybrid action of GABA mediates inhibitory feedback in the mammalian retina.PLoS biology · 2019Article
- Localizing Proton-Mediated Inhibitory Feedback at the Retinal Horizontal Cell-Cone Synapse with Genetically-Encoded pH Probes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Eliminating Glutamatergic Input onto Horizontal Cells Changes the Dynamic Range and Receptive Field Organization of Mouse Retinal Ganglion Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Negative feedback from horizontal cells to cone photoreceptors is regarded as the critical pathway for the formation of the antagonistic surround of retinal neurons, yet the mechanism by which horizontal cells accomplish negative feedback has been difficult to determine. Recent evidence suggests that feedback uses a novel, non-GABAergic pathway that directly modulates the calcium current in cones. In non-mammalian vertebrates, enrichment of retinal pH buffering capacity attenuates horizontal cell feedback, supporting one model in which feedback occurs by horizontal cell modulation of the extracellular pH in the cone synaptic cleft. Here we test the effect of exogenous pH buffering on the response dynamics of H1 horizontal cells and the center-surround receptive field structure of parasol ganglion cells in the macaque monkey retina. Enrichment of the extracellular buffering capacity with HEPES selectively attenuates surround antagonism in parasol ganglion cells. The H1 horizontal cell light response includes a slow, depolarizing component that is attributed to negative feedback to cones. This part of the response is attenuated by HEPES and other pH buffers in a dose-dependent manner that is correlated with predicted buffering capacity. The selective effects of pH buffering on the parasol cell surround and H1 cell light response suggests that, in primate retina, horizontal cell feedback to cones is mediated via a pH-dependent mechanism and is a major determinant of the ganglion cell receptive field surround.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.