ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Oxytocin-induced postinhibitory rebound firing facilitates bursting activity in oxytocin neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Comparison of the effect of breast pump stimulation and oxytocin administration on the length of the third stage of labor, postpartum hemorrhage, and anemia: a randomized controlled trial.BMC pregnancy and childbirth · 2018Trial
- SNAP-47 mediates somatic oxytocin dynamics in hypothalamic neurons.Communications biology · 2026Article
- Neurotransmitter co-transmission: synaptic architectures, functional logic, and emerging tools.Frontiers in molecular neuroscience · 2026Review
- Endolysosomal TPCs regulate social behavior by controlling oxytocin secretion.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Lactation induces increased IPSC bursting in oxytocinergic neurons.Physiological reports · 2019Article
- Electrophysiological properties of identified oxytocin and vasopressin neurones.Journal of neuroendocrinology · 2019Review
- Phosphatidylinositol 4,5-bisphosphate (PIPThe Journal of physiology · 2017Article
- Functional consequences of neuropeptide and small-molecule co-transmission.Nature reviews. Neuroscience · 2017Review
- Electrophysiology of Hypothalamic Magnocellular Neurons In vitro: A Rhythmic Drive in Organotypic Cultures and Acute Slices.Frontiers in neuroscience · 2016Article
- Local oxytocin tempers anxiety by activating GABAA receptors in the hypothalamic paraventricular nucleus.Psychoneuroendocrinology · 2016Article
- Oxytocin Stimulates Extracellular Ca2+ Influx Through TRPV2 Channels in Hypothalamic Neurons to Exert Its Anxiolytic Effects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Neuroendocrine-autonomic integration in the paraventricular nucleus: novel roles for dendritically released neuropeptides.Journal of neuroendocrinology · 2015Review
- Characteristics of GABAergic and cholinergic neurons in perinuclear zone of mouse supraoptic nucleus.Journal of neurophysiology · 2015Article
- Emotion and mood adaptations in the peripartum female:complementary contributions of GABA and oxytocin.Journal of neuroendocrinology · 2014Review
- Short-term potentiation of GABAergic synaptic inputs to vasopressin and oxytocin neurones.The Journal of physiology · 2014Article
- Oxytocin and vasopressin agonists and antagonists as research tools and potential therapeutics.Journal of neuroendocrinology · 2012Review
- MMPs and soluble ICAM-5 increase neuronal excitability within in vitro networks of hippocampal neurons.PloS one · 2012Article
- Prolactin induces a hyperpolarising current in rat paraventricular oxytocinergic neurones.Journal of neuroendocrinology · 2011Article
- Performance, properties and plasticity of identified oxytocin and vasopressin neurones in vitro.Journal of neuroendocrinology · 2010Review
- Synchronized bursts of miniature inhibitory postsynaptic currents.The Journal of physiology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During parturition and lactation, neurosecretory oxytocin (OT) neurons in the hypothalamus achieve pulsatile hormone secretion by coordinated bursts of firing that occur throughout the neuronal population. This activity is partly controlled by somatodendritic release of OT, which facilitates the onset and recurrence of synchronized bursting. To further investigate the cellular mechanisms underlying the control exerted by OT on the activity of its own neurons, we studied the effects of the peptide on membrane potential and synaptic activity in OT neurons in hypothalamic organotypic slice cultures. Bath application of low concentrations of OT (<100 nM) facilitated GABA(A) receptor-mediated inhibitory transmission through a presynaptic mechanism without affecting membrane potential and excitatory glutamatergic synaptic activity. The facilitatory action of OT on GABAergic transmission was dose-dependent, starting at 25 nM and disappearing at concentrations >100 nM. As shown previously, higher concentrations of OT (>500 nM) had the opposite effect, inhibiting GABA(A) receptors via a postsynaptic mechanism. Surprisingly, OT-mediated facilitation of GABAergic transmission promoted action potential firing in 40% of the neurons. Each action potential occurred at the end of the repolarizing phase of an inhibitory potential. Pharmacological dissection revealed that this firing involved the activation of low-threshold activated calcium channels. Detailed statistical analysis showed that OT-mediated firing upregulated bursting activity in OT neurons. It is thus likely to optimize OT secretion and, as a consequence, facilitate delivery and milk ejection in mammals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.