Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Reduced brainstem inhibition during anticipated pelvic visceral pain correlates with enhanced brain response to the visceral stimulus in women with irritable bowel syndrome.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02874495 (Anticipation Effect on Painful Phenomenons Linked to Rectal Distension for Patients With a Crohn's Disease in Remission), which is not on this map. Cited by 104 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Anticipation Effect on Painful Phenomenons Linked to Rectal Distension for Patients With a Crohn's Disease in Remission: Functional MRI Study
Who cites it
104 citing papers in PubMed, 2 syntheses or guidelines pooled it, 236 citations in OpenAlex.
- Neural correlates of somatoform disorders from a meta-analytic perspective on neuroimaging studies.NeuroImage. Clinical · 2016Pooled it
- Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome.Gastroenterology · 2011Pooled it
- Efficacy and Safety of the Enterosorbent Silicolgel in Irritable Bowel Syndrome, IBS-D and IBS-M: A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Trial.Neurogastroenterology and motility · 2025Trial
- Effect of hypnotherapy and educational intervention on brain response to visceral stimulus in the irritable bowel syndrome.Alimentary pharmacology & therapeutics · 2013Trial
- Corticotropin-releasing factor receptor 1 antagonist alters regional activation and effective connectivity in an emotional-arousal circuit during expectation of abdominal pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Trial
- Serum correlates of the placebo effect in irritable bowel syndrome.Neurogastroenterology and motility · 2010Trial
- Neural and psychological predictors of treatment response in irritable bowel syndrome patients with a 5-HT3 receptor antagonist: a pilot study.Alimentary pharmacology & therapeutics · 2008Trial
- A Comprehensive Mendelian Randomization Study of Bidirectional Causal Relationships Between Pain and Mental Disorders.Journal of pain research · 2026Article
- The Neuroanatomical Correlates of Visceral Pain: An Activation Likelihood Estimation Meta-Analysis.Brain sciences · 2025Review
- Deep brain stimulation for obsessive compulsive disorder leads to symptom changes of comorbid irritable bowel syndrome.Frontiers in psychiatry · 2025Article
- The Role of the Insula in Chronic Pain and Associated Structural Changes: An Integrative Review.Cureus · 2024Review
- Aberrant intrinsic brain activities in functional gastrointestinal disorders revealed by seed-based d mapping with permutation of subject images.Frontiers in neuroscience · 2024Review
- Gut Microbiome-Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders.ACS chemical neuroscience · 2023Review
- The neurobiology of irritable bowel syndrome.Molecular psychiatry · 2023Review
- A multi-omic brain gut microbiome signature differs between IBS subjects with different bowel habits.Neuropharmacology · 2023Review
- Efficacy of the Enteroadsorbent Silicol®gel in Adults with Irritable Bowel Syndrome Subtypes IBS-D or Mixed: Observational Open-Label Study.Gastroenterology research and practice · 2023Article
- Neuroimaging Assessment of Pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Microglia-derived TNF-α inhibiting GABAergic neurons in the anterior lateral bed nucleus of the stria terminalis precipitates visceral hypersensitivity induced by colorectal distension in rats.Neurobiology of stress · 2022Article
- Functional Neuroimaging in Irritable Bowel Syndrome: A Systematic Review Highlights Common Brain Alterations With Functional Movement Disorders.Journal of neurogastroenterology and motility · 2022Review
- The Interplay between Autonomic Nervous System and Inflammation across Systemic Autoimmune Diseases.International journal of molecular sciences · 2022Review
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Cognitive factors such as fear of pain and symptom-related anxiety play an important role in chronic pain states. The current study sought to characterize abnormalities in preparatory brain response before aversive pelvic visceral distention in irritable bowel syndrome (IBS) patients and their possible relationship to the consequences of distention. The brain functional magnetic resonance imaging (fMRI) blood oxygen level-dependent (BOLD) response to anticipated and delivered mild and moderate rectal distention was recorded from 14 female IBS patients and 12 healthy controls. During cued anticipation of distention, activity decreased in the insula, supragenual anterior cingulate cortex (sACC), amygdala, and dorsal brainstem (DBS) of controls. IBS patients showed less anticipatory inactivation. Group differences were significant in the right posterior insula and bilateral DBS. Self-rated measures of negative affect during scanning were higher in patients than controls (p < 0.001), and the anticipatory BOLD decreases in DBS were inversely correlated with these ratings. During subsequent distention, both groups showed activity increases in insula, dorsal ACC, and DBS and decreases in the infragenual ACC. The increases were more extensive in patients, producing significant group differences in dorsal ACC and DBS. The amplitude of the anticipatory decrease in the pontine portion of DBS was associated with greater activation during distention in right orbitofrontal cortex and bilateral sACC. Both regions have been associated previously with corticolimbic inhibition and cognitive coping. Deficits in preparatory inhibition of DBS, including the locus ceruleus complex and parabrachial nuclei, may interfere with descending corticolimbic inhibition and contribute to enhanced brain responsiveness and perceptual sensitivity to visceral stimuli in IBS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.