ArticleAmerican journal of physiology. Renal physiology2008
Membrane current oscillations in descending vasa recta pericytes.
Article in American journal of physiology. Renal physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Role of ANO1 CaPflugers Archiv : European journal of physiology · 2025Article
- Orai, RyR, and IPCommunications biology · 2023Article
- The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes.Frontiers in cellular neuroscience · 2020Review
- Introduction to ion channels and calcium signaling in the microcirculation.Current topics in membranes · 2020Review
- Pericytes in the renal vasculature: roles in health and disease.Nature reviews. Nephrology · 2018Review
- Properties of synchronous spontaneous CaPflugers Archiv : European journal of physiology · 2017Article
- Spontaneous activity in the microvasculature of visceral organs: role of pericytes and voltage-dependent Ca(2+) channels.The Journal of physiology · 2016Review
- Descending Vasa Recta Endothelial Membrane Potential Response Requires Pericyte Communication.PloS one · 2016Article
- Renal autoregulation in health and disease.Physiological reviews · 2015Review
- Syncytial communication in descending vasa recta includes myoendothelial coupling.American journal of physiology. Renal physiology · 2014Article
- Descending vasa recta endothelial cells and pericytes form mural syncytia.American journal of physiology. Renal physiology · 2014Article
- Disruption of vascular Ca2+-activated chloride currents lowers blood pressure.The Journal of clinical investigation · 2014Article
- Mural propagation of descending vasa recta responses to mechanical stimulation.American journal of physiology. Renal physiology · 2013Article
- Functional and morphological properties of pericytes in suburothelial venules of the mouse bladder.British journal of pharmacology · 2012Article
- Mechanisms of vasopressin-induced intracellular Ca2+ oscillations in rat inner medullary collecting duct.American journal of physiology. Renal physiology · 2011Article
- Murine vasa recta pericyte chloride conductance is controlled by calcium, depolarization, and kinase activity.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Chronic ouabain treatment induces vasa recta endothelial dysfunction in the rat.American journal of physiology. Renal physiology · 2009Article
- Mechanisms underlying angiotensin II-induced calcium oscillations.American journal of physiology. Renal physiology · 2008Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We investigated the origin of spontaneous transient inward current (STIC) oscillations in descending vasa recta (DVR) pericytes. In cells clamped at -80 mV, angiotensin II (ANG II; 10 nmol/l) induced oscillations with mean amplitude and frequency of -65.5 pA and 1.2 Hz. Simultaneous recording of cytoplasmic calcium ([Ca(2+)](CYT)) and membrane current oscillations verified their synchrony and the correlation of their amplitudes. Confocal recording in fluo-4-loaded DVR showed that ANG II can induce either stable pericyte [Ca(2+)](CYT) elevation or oscillations, while decreasing adjacent endothelial [Ca(2+)](CYT). Oscillating currents reversed sign at -30.2 mV and were blocked by niflumic acid, implicating charge transfer via Cl(-) ion. Removal of extracellular Ca(2+), blockade of Ca(2+) influx with SKF96365 (30 micromol/l), ryanodine (30 micromol/l), or caffeine (10 mmol/l) inhibited oscillations. In contrast, they were insensitive to removal of extracellular Na(+) and exposure to either nifedipine (1 micromol/l) or 2-aminoethoxydiphenyl borate (10 micromol/l). Ouabain (100 nmol/l) increased basal pericyte [Ca(2+)](CYT) and the frequency of resting STICs but did not affect the larger oscillations that followed ANG II stimulation. We conclude that [Ca(2+)](CYT) oscillations stimulate Cl(-) currents. The former are most likely maintained by repetitive cycles of ryanodine-sensitive SR Ca(2+) release and SKF96365-sensitive store refilling.
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