ArticleRheumatology (Oxford, England)2008
Arthritis risk after acute bacterial gastroenteritis.
Article in Rheumatology (Oxford, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Chronic sequelae of E. coli O157: systematic review and meta-analysis of the proportion of E. coli O157 cases that develop chronic sequelae.Foodborne pathogens and disease · 2014Pooled it
- Article
- Resistance to Antibiotics in Thermophilic Campylobacters.Frontiers in medicine · 2021Review
- Exploring Changes in the Host Gut Microbiota During a Controlled Human Infection Model forFrontiers in cellular and infection microbiology · 2021Article
- Characteristics of hospitalized patients during a large waterborne outbreak of Campylobacter jejuni in Norway.PloS one · 2021Article
- Article
- A controlled survey of less typical long-term consequences after an extensive waterborne epidemic.BMC infectious diseases · 2017Article
- Contrasting immune responses mediate Campylobacter jejuni-induced colitis and autoimmunity.Mucosal immunology · 2014Article
- Article
- Outcome of reactive arthritis after an extensive Finnish waterborne gastroenteritis outbreak: a 1-year prospective follow-up study.Clinical rheumatology · 2013Article
- Chronic Lyme Disease and Co-infections: Differential Diagnosis.The open neurology journal · 2012Article
- Waterborne outbreak of gastroenteritis: effects on sick leaves and cost of lost workdays.PloS one · 2012Article
- New perspectives in monitoring drinking water microbial quality.International journal of environmental research and public health · 2010Review
- The epidemiology of infectious gastroenteritis related reactive arthritis in U.S. military personnel: a case-control study.BMC infectious diseases · 2010Article
- Long-term health risks for children and young adults after infective gastroenteritis.Emerging infectious diseases · 2010Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectivesReactive arthritis (ReA) may occur from bacterial gastroenteritis. We studied the risk of arthritis after an outbreak of Escherichia coli O157:H7 and Campylobacter species within a regional drinking water supply to examine the relationship between the severity of acute diarrhoea and subsequent symptoms of arthritis.
methodsParticipants with no known history of arthritis before the outbreak participated in a long-term follow-up study. Of the 2299 participants, 788 were asymptomatic during the outbreak, 1034 had moderate symptoms of acute gastroenteritis and 477 had severe symptoms that necessitated medical attention. The outcomes of interest were new arthritis by self-report and a new prescription of medication for arthritis during the follow-up period.
resultsAfter a mean follow-up of 4.5 yrs after the outbreak, arthritis was reported in 15.7% of participants who had been asymptomatic during the outbreak, and in 17.6 and 21.6% of those who had moderate and severe symptoms of acute gastroenteritis, respectively (P-value for trend = 0.009). Compared with the asymptomatic participants, those with moderate and severe symptoms of gastroenteritis had an adjusted relative risk of arthritis of 1.19 [95% confidence interval (CI) 0.99-1.43] and 1.33 (95% CI 1.07-1.66), respectively. No association was observed between gastroenteritis and the subsequent risk of prescription medication for arthritis (P = 0.49).
conclusionsAcute bacterial gastroenteritis necessitating medical attention was associated with a higher risk of arthritic symptoms, but not arthritic medications, up to 4 yrs afterwards. The nature and chronicity of these arthritic symptoms requires further study.
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Registered trials
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