ArticleThe Journal of biological chemistry2008
Phosphorylation of CtBP1 by cAMP-dependent protein kinase modulates induction of CYP17 by stimulating partnering of CtBP1 and 2.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Dynamic microRNA expression profiles in goat ovarian tissues before and after pregnancy.Journal of animal science · 2025Article
- Role of miRNAs interference on ovarian functions and premature ovarian failure.Cell communication and signaling : CCS · 2022Review
- Prostaglandins and calprotectin are genetically and functionally linked to the Inflammatory Bowel Diseases.PLoS genetics · 2022Article
- MicroRNA in Ovarian Biology and Disease.Cold Spring Harbor perspectives in medicine · 2015Review
- Article
- Components of the CtBP1/BARS-dependent fission machinery.Histochemistry and cell biology · 2013Review
- PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1.Journal of molecular biology · 2013Article
- Characterization and differential expression of microRNAs in the ovaries of pregnant and non-pregnant goats (Capra hircus).BMC genomics · 2013Article
- C-Terminal Binding Protein: A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer.International journal of cell biology · 2013Article
- Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450scc.Endocrinology · 2012Article
- TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition.The EMBO journal · 2011Article
- Preventing granulosa cell apoptosis through the action of a single microRNA.Biology of reproduction · 2010Article
- Minireview: steroidogenic factor 1: its roles in differentiation, development, and disease.Molecular endocrinology (Baltimore, Md.) · 2010Review
- Role of Dicer in female fertility.Trends in endocrinology and metabolism: TEM · 2009Review
- MicroRNA in the ovary and female reproductive tract.Journal of animal science · 2009Review
- Complex assembly on the human CYP17 promoter.Molecular and cellular endocrinology · 2009Review
- Hormonal regulation of MicroRNA expression in periovulatory mouse mural granulosa cells.Biology of reproduction · 2008Article
- Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.Genes & development · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In the human adrenal cortex, the peptide hormone adrenocorticotropin (ACTH) directs cortisol and adrenal androgen biosynthesis by activating a cAMP/cAMP-dependent protein kinase (PKA) pathway. Carboxyl-terminal binding protein 1 (CtBP1) is a corepressor that regulates transcription of the CYP17 gene by periodically interacting with steroidogenic factor-1 in response to ACTH signaling. Given that CtBP1 function is regulated by NADH binding, we hypothesized that ACTH-stimulated changes in cellular pyridine nucleotide concentrations modulate the ability of CtBP1 to repress CYP17 transcription. Further, we postulated that PKA evokes changes in the phosphorylation status of CtBP1 that control the ability of the protein to bind to steroidogenic factor-1 and the coactivator GCN5 (general control nonderepressed 5) and repress CYP17 gene expression. We show that ACTH alters pyridine nucleotide redox state and identify amino acid residues in CtBP1 that are targeted by PKA and PAK6. Both ACTH/cAMP signaling and NADH/NAD+ ratio stimulate nuclear-cytoplasmic oscillation of both CtBP proteins. We provide evidence that PKA 1) induces metabolic changes in the adrenal cortex and 2) phosphorylates CtBP proteins, particularly CtBP1 at T144, resulting in CtBP protein partnering and ACTH-dependent CYP17 transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.