Trial reportBMJ (Clinical research ed.)2008
Zinc supplementation in children with cholera in Bangladesh: randomised controlled trial.
Trial report in BMJ (Clinical research ed.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00226616 (Clinical Trial of Zinc Supplementation in Cholera Patients), which is not on this map. Cited by 31 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Trial of Zinc Supplementation in Cholera Patients
Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Zinc supplementation for acute and persistent watery diarrhoea in children: A systematic review and meta-analysis.Journal of global health · 2024Pooled it
- Oral zinc for treating diarrhoea in children.The Cochrane database of systematic reviews · 2016Pooled it
- Zinc supplements for preventing otitis media.The Cochrane database of systematic reviews · 2014Pooled it
- Therapeutic value of zinc supplementation in acute and persistent diarrhea: a systematic review.PloS one · 2010Pooled it
- Saccharomyces boulardii and bismuth subsalicylate as low-cost interventions to reduce the duration and severity of cholera.Pathogens and global health · 2015Trial
- Zinc inhibits cAMP-induced ClAmerican journal of physiology. Cell physiology · 2025Article
- Metal Ion Signaling in Biomedicine.Chemical reviews · 2025Review
- Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets.Signal transduction and targeted therapy · 2024Review
- Evaluation of Micronutrients and Pro-Inflammatory Cytokines Levels in Nutritionally Deprived Children-A Tertiary Care Hospital-Based Study.Nutrients · 2023Article
- Diagnosis, Management, and Future Control of Cholera.Clinical microbiology reviews · 2022Review
- Inhibition of α-, β- and γ-carbonic anhydrases from the pathogenic bacteriumJournal of enzyme inhibition and medicinal chemistry · 2021Article
- Beneficial Effects of Plant Extracts and Bioactive Food Components in Childhood Supplementation.Nutrients · 2021Review
- A retrospective mixed-methods evaluation of a national ORS and zinc scale-up program in Uganda between 2011 and 2016.Journal of global health · 2019Article
- Cholera.Current epidemiology reports · 2018Article
- Burden and Risk Factors of Antimicrobial Use in Children Less Than 5 Years of Age with Diarrheal Illness in Rural Bangladesh.The American journal of tropical medicine and hygiene · 2018Article
- Factors Associated with the Duration of Moderate-to-Severe Diarrhea among Children in Rural Western Kenya Enrolled in the Global Enteric Multicenter Study, 2008-2012.The American journal of tropical medicine and hygiene · 2017Article
- Achievements and challenges for the use of killed oral cholera vaccines in the global stockpile era.Human vaccines & immunotherapeutics · 2017Review
- Effect of Dietary Minerals on Virulence Attributes ofFrontiers in microbiology · 2017Article
- Seroepidemiologic survey of epidemic cholera in Haiti to assess spectrum of illness and risk factors for severe disease.The American journal of tropical medicine and hygiene · 2013Article
- Zinc: Role in the management of diarrhea and cholera.World journal of clinical cases · 2013Review
Corrections and comments
- Commented on by
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo investigate the impact of zinc supplementation in children with cholera.
designDouble blind, randomised, placebo controlled trial.
settingDhaka Hospital, Bangladesh.
participants179 children aged 3-14 years with watery diarrhoea and stool dark field examination positive for Vibrio cholerae and confirmed by stool culture.
interventionChildren were randomised to receive 30 mg elemental zinc per day (n=90) or placebo (n=89) until recovery. All children received erythromycin suspension orally in a dose of 12.5 mg/kg every six hours for three days.
main outcome measuresDuration of diarrhoea and stool output. Results 82 children in each group completed the study. More patients in the zinc group than in the control group recovered by two days (49% v 32%, P=0.032) and by three days (81% v 68%, P=0.03). Zinc supplemented patients had 12% shorter duration of diarrhoea than control patients (64.1 v 72.8 h, P=0.028) and 11% less stool output (1.6 v 1.8 kg/day, P=0.039).
conclusionZinc supplementation significantly reduced the duration of diarrhoea and stool output in children with cholera. Children with cholera should be supplemented with zinc to reduce its duration and severity.
trial registrationClinical trials NCT00226616.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.