ArticleCurrent genetics2008
Gene expression in the regulation of carotene biosynthesis in Phycomyces.
Article in Current genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 57 citations in OpenAlex.
- Beyond enzymes and organic acids, solid-state fermentation as an alternative for valorizing fruits and vegetable wastes into novel bio-products in a circular economy: A critical review.AIMS microbiology · 2025Review
- Transcriptome sequencing and global analysis of blue light-responsive genes provide clues for high carotenoid yields in Blakeslea trispora.International microbiology : the official journal of the Spanish Society for Microbiology · 2022Article
- Carotenoids and Their Biosynthesis in Fungi.Molecules (Basel, Switzerland) · 2022Review
- Deregulation of phytoene-β-carotene synthase results in derepression of astaxanthin synthesis at high glucose concentration in Phaffia rhodozyma astaxanthin-overproducing strain MK19.BMC microbiology · 2019Article
- Carotenoid Cleavage Oxygenases from Microbes and Photosynthetic Organisms: Features and Functions.International journal of molecular sciences · 2016Review
- A new regulatory mechanism controlling carotenogenesis in the fungus Mucor circinelloides as a target to generate β-carotene over-producing strains by genetic engineering.Microbial cell factories · 2016Article
- Biological roles of fungal carotenoids.Current genetics · 2015Review
- Biotechnological production of carotenoids by yeasts: an overview.Microbial cell factories · 2014Review
- The family structure of the Mucorales: a synoptic revision based on comprehensive multigene-genealogies.Persoonia · 2013Article
- Functional analysis of the carS gene of Fusarium fujikuroi.Molecular genetics and genomics : MGG · 2013Article
- Crocins with high levels of sugar conjugation contribute to the yellow colours of early-spring flowering crocus tepals.PloS one · 2013Article
- Adaptation of the black yeast Wangiella dermatitidis to ionizing radiation: molecular and cellular mechanisms.PloS one · 2012Article
- Analysis of al-2 mutations in Neurospora.PloS one · 2011Article
- Functional analysis of the Phycomyces carRA gene encoding the enzymes phytoene synthase and lycopene cyclase.PloS one · 2011Article
- Light regulation of metabolic pathways in fungi.Applied microbiology and biotechnology · 2010Review
- Effects of an ergosterol synthesis inhibitor on gene transcription of terpenoid biosynthesis in Blakeslea trispora.Current microbiology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carotene synthesis in the Mucoral fungus, Phycomyces blakesleeanus, is regulated by a complex genetic mechanism and activated by four groups of environmental factors with independent mechanisms of action. Blue light and sexual stimulation increased in parallel the content of carotene and the content of mRNAs from the genes, carRA and carB, dedicated to the synthesis of beta-carotene from geranylgeranyl pyrophosphate. The effects of these agents were approximately additive. Retinol and dimethyl phthalate, which represent the remaining groups of activators, greatly increased the carotene content, but did not modify the levels of carRA and carB transcripts. Mutants in genes carRA, carB, carC, carD, carF, carI, and carS differed in their carotene content, from nil to much larger than that of the wild type, but had the same carRA and carB transcript levels as the wild type. The only exception was a carRA early-stop mutant, which had very small amounts of the carRA transcript. The genetic and environmental factors that modify carotene biosynthesis had little or no effect on the mRNA levels of genes, hmgS and hmgR, responsible for the enzymes that initiate the biosynthesis of all terpenoids. A general model for the regulation of carotenogenesis in Phycomyces was derived from the results.
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