ArticleCurrent genetics2008
Lager yeasts possess dynamic genomes that undergo rearrangements and gene amplification in response to stress.
Article in Current genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 89 citations in OpenAlex.
- Molecular evolution in light of regulatory-coding epistasis.EMBO reports · 2026Review
- Gene abundance linked to climate zone: Parallel evolution of gene content along elevation gradients in lichenized fungi.Frontiers in microbiology · 2023Article
- Aneuploidy influences the gene expression profiles in Saccharomyces pastorianus group I and II strains during fermentation.PLoS genetics · 2022Article
- Packing a punch: understanding how flavours are produced in lager fermentations.FEMS yeast research · 2021Review
- Poly-aneuploid cancer cells promote evolvability, generating lethal cancer.Evolutionary applications · 2020Article
- Convergent Evolution, Evolving Evolvability, and the Origins of Lethal Cancer.Molecular cancer research : MCR · 2020Review
- Lager-brewing yeasts in the era of modern genetics.FEMS yeast research · 2019Review
- Expression of Novel Gene Content Drives Adaptation to Low Iron in the Cyanobacterium Acaryochloris.Genome biology and evolution · 2018Article
- Antagonistic evolution of an antibiotic and its molecular chaperone: how to maintain a vital ectosymbiosis in a highly fluctuating habitat.Scientific reports · 2017Article
- hsp90 and hsp47 appear to play an important role in minnow Puntius sophore for surviving in the hot spring run-off aquatic ecosystem.Fish physiology and biochemistry · 2017Article
- Novel brewing yeast hybrids: creation and application.Applied microbiology and biotechnology · 2017Review
- Relationships between rDNA, Nop1 and Sir complex in biotechnologically relevant distillery yeasts.Archives of microbiology · 2016Article
- Copy number variations of genes involved in stress responses reflect the redox state and DNA damage in brewing yeasts.Cell stress & chaperones · 2016Article
- Whole Genome Analysis of 132 Clinical Saccharomyces cerevisiae Strains Reveals Extensive Ploidy Variation.G3 (Bethesda, Md.) · 2016Article
- Comparative genomics and transcriptomics of Pichia pastoris.BMC genomics · 2016Article
- Adaptive response to chronic mild ethanol stress involves ROS, sirtuins and changes in chromosome dosage in wine yeasts.Oncotarget · 2016Article
- The Genome Sequence of Saccharomyces eubayanus and the Domestication of Lager-Brewing Yeasts.Molecular biology and evolution · 2015Article
- Engineering Saccharomyces pastorianus for the co-utilisation of xylose and cellulose from biomass.Microbial cell factories · 2015Article
- Shifts in rDNA levels act as a genome buffer promoting chromosome homeostasis.Cell cycle (Georgetown, Tex.) · 2015Article
- Lager yeast comes of age.Eukaryotic cell · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A long-term goal of the brewing industry is to identify yeast strains with increased tolerance to the stresses experienced during the brewing process. We have characterised the genomes of a number of stress-tolerant mutants, derived from the lager yeast strain CMBS-33, that were selected for tolerance to high temperatures and to growth in high specific gravity wort. Our results indicate that the heat-tolerant strains have undergone a number of gross chromosomal rearrangements when compared to the parental strain. To determine if such rearrangements can spontaneously arise in response to exposure to stress conditions experienced during the brewing process, we examined the chromosome integrity of both the stress-tolerant strains and their parent during a single round of fermentation under a variety of environmental stresses. Our results show that the lager yeast genome shows tremendous plasticity during fermentation, especially when fermentations are carried out in high specific gravity wort and at higher than normal temperatures. Many localised regions of gene amplification were observed especially at the telomeres and at the rRNA gene locus on chromosome XII, and general chromosomal instability was evident. However, gross chromosomal rearrangements were not detected, indicating that continued selection in the stress conditions are required to obtain clonal isolates with stable rearrangements. Taken together, the data suggest that lager yeasts display a high degree of genomic plasticity and undergo genomic changes in response to environmental stress.
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