ArticleInternational urogynecology journal and pelvic floor dysfunction2008
Comparative histological analysis of anterior vaginal wall in women with pelvic organ prolapse or control subjects. A pilot study.
Article in International urogynecology journal and pelvic floor dysfunction, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 61 citations in OpenAlex.
- 3D MRI Biomarkers for Predicting Pelvic Organ Prolapse Risk and Severity.International urogynecology journal · 2026Article
- Morphological changes in the anterior vaginal wall caused by aging: a scanning electron microscopy study.International urogynecology journal · 2023Article
- Role of fibulin-5 insufficiency and prolapse progression on murine vaginal biomechanical function.Scientific reports · 2021Article
- Contractile Properties of Vaginal Tissue.Journal of biomechanical engineering · 2020Review
- Extracellular Matrix Stiffness and Composition Regulate the Myofibroblast Differentiation of Vaginal Fibroblasts.International journal of molecular sciences · 2020Article
- Smooth muscle regional contribution to vaginal wall function.Interface focus · 2019Article
- Ovine multiparity is associated with diminished vaginal muscularis, increased elastic fibres and vaginal wall weakness: implication for pelvic organ prolapse.Scientific reports · 2017Article
- Does the vaginal wall become thinner as prolapse grade increases?International urogynecology journal · 2017Observational
- Vaginal Fibroblastic Cells from Women with Pelvic Organ Prolapse Produce Matrices with Increased Stiffness and Collagen Content.Scientific reports · 2016Article
- Changes in elastin density in different locations of the vaginal wall in women with pelvic organ prolapse.International urogynecology journal · 2014Article
- Histology of the vaginal wall in women with pelvic organ prolapse: a literature review.International urogynecology journal · 2013Review
- The improvement of pelvic floor muscle function in POP patients after the Prolift procedure: results from surface electromyography.International urogynecology journal · 2013Article
- Effect of estrogen on molecular and functional characteristics of the rodent vaginal muscularis.The journal of sexual medicine · 2013Article
- Regional differences in rat vaginal smooth muscle contractility and morphology.Reproductive sciences (Thousand Oaks, Calif.) · 2013Article
- Immunohistochemical analysis of connective tissue in patients with pelvic organ prolapse.Journal of molecular histology · 2013Article
- In vitro and in vivo assessment of silver-coated polypropylene mesh to prevent infection in a rat model.International urogynecology journal · 2011Article
- Ultrasound measurement of vaginal wall thickness: a novel and reliable technique.International urogynecology journal · 2010Article
- Alteration of vaginal elastin metabolism in women with pelvic organ prolapse.Obstetrics and gynecology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to compare smooth muscle content of anterior vaginal wall in women with pelvic organ prolapse (POP) and control subjects. Specimens were taken in the midline from the apex of anterior vaginal cuff from eleven women with POP and eight control subjects operated for hysterectomy without prolapse. Masson's trichrome stain was used to determine the distribution of collagen in the extracellular matrix of the vaginal muscularis and to quantify the collagen in area of interest. Slides of alpha smooth muscle actin were detected using antibodies. Morphometric analysis was used to compare and to quantify the smooth muscle content of the vaginal muscularis. Fractional area of nonvascular vaginal smooth muscle of women with POP was significantly decreased in comparison to control subjects (41.9 vs 61.9%, p = 0.005). Fractional area of connective tissue was significantly increased (56.8 vs 35%, p = 0.004). Fractional area of blood vessels was similar (2.2 vs 3.4%, p = 0.20).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.