Evidence map›Paper›PMID 18182698›Full record

ArticlePhysics in medicine and biology2008

Evaluation of rapid dual-tracer (62)Cu-PTSM + (62)Cu-ATSM PET in dogs with spontaneously occurring tumors.

Noel F Black, Scott McJames, Thomas C Rust, Dan J Kadrmas

Open access · greenAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Physics in medicine and biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 41 citations in OpenAlex.

  1. Diagnostic Imaging Features of Mammary Gland Tumors in Dogs and Cats.Animals : an open access journal from MDPI · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. PET Parametric Imaging: Past, Present, and Future.IEEE transactions on radiation and plasma medical sciences · 2020
    Article
  7. Review
  8. Review
  9. Defining the Value of a Comparative Approach to Cancer Drug Development.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016
    Review
  10. Article
  11. Kinetic modeling in PET imaging of hypoxia.American journal of nuclear medicine and molecular imaging · 2014
    Review
  12. (18)F-alfatide II and (18)F-FDG dual-tracer dynamic PET for parametric, early prediction of tumor response to therapy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2014
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Development of copper based drugs, radiopharmaceuticals and medical materials.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2012
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Noel F BlackUtah Center of Advanced Imaging Research, University of Utah, 729 Arapeen Drive, Salt Lake City, UT 84108-1218, USA.
Scott McJames
Thomas C Rust
Dan J Kadrmas
Advanced Imaging Research (United States) · USUniversity of Utah · US

Funding

Multi-Tracer PET Tumor ImagingR01CA135556 · NCI · UNIVERSITY OF UTAH · PI KADRMAS, DAN J · 2009 to 2017
$2.8M
NCI NIH HHS R01 CA135556
6 · The paper itself

Abstract

We are developing methods for imaging multiple PET tracers in a single scan with staggered injections, where imaging measures for each tracer are separated and recovered using differences in tracer kinetics and radioactive decay. In this work, signal separation performance for rapid dual-tracer (62)Cu-PTSM (blood flow) + (62)Cu-ATSM (hypoxia) tumor imaging was evaluated in a large animal model. Four dogs with pre-existing tumors received a series of dynamic PET scans with (62)Cu-PTSM and (62)Cu-ATSM, permitting evaluation of a rapid dual-tracer protocol designed by previous simulation work. Several imaging measures were computed from the dual-tracer data and compared with those from separate, single-tracer imaging. Static imaging measures (e.g. SUV) for each tracer were accurately recovered from dual-tracer data. The wash-in (k(1)) and wash-out (k(2)) rate parameters for both tracers were likewise well recovered (r = 0.87-0.99), but k(3) was not accurately recovered for PTSM (r = 0.19) and moderately well recovered for ATSM (r = 0.70). Some degree of bias was noted, however, which may potentially be overcome through further refinement of the signal separation algorithms. This work demonstrates that complementary information regarding tumor blood flow and hypoxia can be acquired by a single dual-tracer PET scan, and also that the signal separation procedure works effectively for real physiologic data with realistic levels of kinetic model mismatch. Rapid multi-tracer PET has the potential to improve tumor assessment for image-guide therapy and monitoring, and further investigation with these and other tracers is warranted.

Indexed as

AlgorithmsAnimalsBiophysical PhenomenaBiophysicsCoordination ComplexesCopper RadioisotopesDog DiseasesDogsFemaleImage Processing, Computer-AssistedNeoplasmsOrganometallic CompoundsPositron-Emission TomographyRadiopharmaceuticalsSignal Processing, Computer-AssistedThiosemicarbazonesCoordination Complexescopper (II) diacetyl-di(N(4)-methylthiosemicarbazone)copper pyruvaldehyde bis(N(4)-methylthiosemicarbazone) complexCopper RadioisotopesOrganometallic CompoundsRadiopharmaceuticalsThiosemicarbazones

Identifiers

PMID18182698
PMCPMC3746544
OpenAlexW2086209836

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.