ArticleNeuro-oncology2008
Identification of a novel proliferation-related protein, WHSC1 4a, in human gliomas.
Article in Neuro-oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Proteomic analysis of cerebrospinal fluid: toward the identification of biomarkers for gliomas.Neurosurgical review · 2014Pooled it
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- The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice.FEBS letters · 2020Article
- Pathogenic and Therapeutic Role of H3K4 Family of Methylases and Demethylases in Cancers.Indian journal of clinical biochemistry : IJCB · 2019Review
- High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.The Journal of biological chemistry · 2018Article
- Article
- Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies.Epigenetics · 2017Review
- In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1 and NSD3/WHSC1L.BMC structural biology · 2014Article
- Article
- Overexpression of MMSET is correlation with poor prognosis in hepatocellular carcinoma.Pathology oncology research : POR · 2013Article
- Differential glioma-associated tumor antigen expression profiles of human glioma cells grown in hypoxia.PloS one · 2012Article
- Proteomics of gliomas: initial biomarker discovery and evolution of technology.Neuro-oncology · 2011Review
- Capillary electrophoresis applied to proteomic analysis.Journal of separation science · 2009Article
- Application of mass spectrometry-based proteomics for biomarker discovery in neurological disorders.Annals of Indian Academy of Neurology · 2009Article
- Proteins inform survival-based differences in patients with glioblastoma.Neuro-oncology advancesArticle
Corrections and comments
- Erratum issuedMushlin, Harry [added]
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
Dynamic changes in the expression of multiple genes appear to be common features that distinguish transformed cells from their normal counterparts. We compared the proteomic profiles of four glioblastoma multiforme (GBM) tissue samples and four normal brain cortex samples to examine the molecular basis of gliomagenesis. Trypsin-digested protein samples were separated by capillary isoelectric focusing with nano-reversed-phase liquid chromatography and were profiled by mass spectrometric sequencing. Wolf-Hirschhorn syndrome candidate 1 (WHSC1), along with 103 other proteins, was found only in the GBM proteomes. Western blot and immunohistochemistry verified our proteomic findings and demonstrated that 30-kDa WHSC1 expression increases with ascending tumor proliferation activity. RNA interference could suppress glioma cell growth by blocking WHSC1 expression. Our novel findings encourage the application of proteomic techniques in cancer research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.