ArticleProceedings of the National Academy of Sciences of the United States of America2008
Phylogeny of endocytic components yields insight into the process of nonendosymbiotic organelle evolution.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates.Nucleic acids research · 2023Article
- AP1/2β-mediated exocytosis of tapetum-specific transporters is required for pollen development in Arabidopsis thaliana.The Plant cell · 2022Article
- A dominant negative variant ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Recurrent sequence evolution after independent gene duplication.BMC evolutionary biology · 2020Article
- Spoiled for Choice: Diverse Endocytic Pathways Function at the Cell Surface.Annual review of cell and developmental biology · 2019Review
- Predominant Golgi Residency of the Plant K/HDEL Receptor Is Essential for Its Function in Mediating ER Retention.The Plant cell · 2018Article
- Evolutionary origins and specialisation of membrane transport.Current opinion in cell biology · 2018Review
- Evolutionary cell biology traces the rise of the exomer complex in Fungi from an ancient eukaryotic component.Scientific reports · 2018Article
- Regulation of early endosomes across eukaryotes: Evolution and functional homology of Vps9 proteins.Traffic (Copenhagen, Denmark) · 2018Article
- An endosomal syntaxin and the AP-3 complex are required for formation and maturation of candidate lysosome-related secretory organelles (mucocysts) inMolecular biology of the cell · 2017Article
- On the Archaeal Origins of Eukaryotes and the Challenges of Inferring Phenotype from Genotype.Trends in cell biology · 2016Review
- Endoplasmosis and exoplasmosis: the evolutionary principles underlying endocytosis, exocytosis, and vesicular transport.Wiener medizinische Wochenschrift (1946) · 2016Review
- Site-directed mutagenesis, in vivo electroporation and mass spectrometry in search for determinants of the subcellular targeting of Rab7b paralogue in the model eukaryote Paramecium octaurelia.European journal of histochemistry : EJH · 2016Article
- Functional analyses of the plant-specific C-terminal region of VPS9a: the activating factor for RAB5 in Arabidopsis thaliana.Journal of plant research · 2016Article
- A multi-functional tubulovesicular network as the ancestral eukaryotic endomembrane system.Biology · 2015Review
- Unexpected ancient paralogs and an evolutionary model for the COPII coat complex.Genome biology and evolution · 2015Article
- Minimization of extracellular space as a driving force in prokaryote association and the origin of eukaryotes.Biology direct · 2014Article
- Missing pieces of an ancient puzzle: evolution of the eukaryotic membrane-trafficking system.Cold Spring Harbor perspectives in biology · 2014Review
- Eukaryotic origins: How and when was the mitochondrion acquired?Cold Spring Harbor perspectives in biology · 2014Review
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3 authors.
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Abstract
The process by which some eukaryotic organelles, for example the endomembrane system, evolved without endosymbiotic input remains poorly understood. This problem largely arises because many major cellular systems predate the last common eukaryotic ancestor (LCEA) and thus do not provide examples of organellogenesis in progress. A model is emerging whereby gene duplication and divergence of multiple "specificity-" or "identity-" encoding proteins for the various endomembranous organelles produced the diversity of nonendosymbiotically derived cellular compartments present in modern eukaryotes. To address this possibility, we analyzed three molecular components of the endocytic membrane-trafficking machinery. Phylogenetic analyses of the endocytic syntaxins, Rab 5, and the beta-adaptins each reveal a pattern of ancestral, undifferentiated endocytic homologues in the LCEA. Subsequently, these undifferentiated progenitors independently duplicated in widely divergent lineages, convergently producing components with similar endocytic roles, e.g., beta1 and beta2-adaptin. In contrast, beta3, beta4, and all other adaptin complex subunits, as well as paralogues of the syntaxins and Rabs specific for the other membrane-trafficking organelles, all evolved before the LCEA. Thus, the process giving rise to the differentiated organelles of the endocytic system appears to have been interrupted by the major speciation event that produced the extant eukaryotic lineages. These results suggest that although many endocytic components evolved before the LCEA, other major features evolved independently and convergently after diversification into the primary eukaryotic supergroups. This finding provides an example of a basic cellular system that was simpler in the LCEA than in many extant eukaryotes and yields insight into nonendosymbiotic organelle evolution.
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