ArticleThe Journal of biological chemistry2008
JunD protects the liver from ischemia/reperfusion injury by dampening AP-1 transcriptional activation.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Analysis of potential immune-related genes involved in the pathogenesis of ischemia-reperfusion injury following liver transplantation.Frontiers in immunology · 2023Article
- Identification of key transcription factors associated with cerebral ischemia‑reperfusion injury based on gene‑set enrichment analysis.International journal of molecular medicine · 2019Article
- Ubiquitin-proteasome system and oxidative stress in liver transplantation.World journal of gastroenterology · 2018Review
- Attenuation of pulmonary ACE2 activity impairs inactivation of des-ArgAmerican journal of physiology. Lung cellular and molecular physiology · 2018Article
- A Review of the Scaffold Protein Menin and its Role in Hepatobiliary Pathology.Gene expression · 2017Review
- Article
- Promoter-distal RNA polymerase II binding discriminates active from inactive CCAAT/ enhancer-binding protein beta binding sites.Genome research · 2015Article
- Network Analysis Shows Novel Molecular Mechanisms of Action for Copper-Based Chemotherapy.Frontiers in physiology · 2015Article
- The basic biology of redoxosomes in cytokine-mediated signal transduction and implications for disease-specific therapies.Biochemistry · 2014Review
- Regulation of molecular pathways in ischemia-reperfusion injury after liver transplantation.Transplantation · 2013Article
- Hepatocytes produce TNF-α following hypoxia-reoxygenation and liver ischemia-reperfusion in a NADPH oxidase- and c-Src-dependent manner.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches.Gastroenterology · 2012Review
- Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- c-Jun and Fra-2 pair up to Myc-anistically drive HCC.Cell cycle (Georgetown, Tex.)Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
The AP-1 transcription factor modulates a wide range of cellular processes, including cellular proliferation, programmed cell death, and survival. JunD is a major component of the AP-1 complex following liver ischemia/reperfusion (I/R) injury; however, its precise function in this setting remains unclear. We investigated the functional significance of JunD in regulating AP-1 transcription following partial lobar I/R injury to the liver, as well as the downstream consequences for hepatocellular remodeling. Our findings demonstrate that JunD plays a protective role, reducing I/R injury to the liver by suppressing acute transcriptional activation of AP-1. In the absence of JunD, c-Jun phosphorylation and AP-1 activation in response to I/R injury were elevated, and this correlated with increased caspase activation, injury, and alterations in hepatocyte proliferation. The expression of dominant negative JNK1 inhibited c-Jun phosphorylation, AP-1 activation, and hepatic injury following I/R in JunD-/- mice but, paradoxically, led to an enhancement of AP-1 activation and liver injury in JunD+/- littermates. Enhanced JunD/JNK1-dependent liver injury correlated with the acute induction of diphenylene iodonium-sensitive NADPH-dependent superoxide production by the liver following I/R. In this context, dominant negative JNK1 expression elevated both Nox2 and Nox4 mRNA levels in the liver in a JunD-dependent manner. These findings suggest that JunD counterbalances JNK1 activation and the downstream redox-dependent hepatic injury that results from I/R, and may do so by regulating NADPH oxidases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.