ArticleJournal of cellular and molecular medicine
Differential expression of microRNAs in myometrium and leiomyomas and regulation by ovarian steroids.
Article in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 106 citations in OpenAlex.
- Effect of luteal-phase support on endometrial microRNA expression following controlled ovarian stimulation.Reproductive biology and endocrinology : RB&E · 2012Trial
- The Role of Estrogen in Brain MicroRNAs Regulation.Advanced pharmaceutical bulletin · 2024Review
- MicroRNAs as potential indicators of the development and progression of uterine leiomyoma.PloS one · 2022Article
- Regulation of breast cancer metastasis signaling by miRNAs.Cancer metastasis reviews · 2020Review
- Tranilast induces MiR-200c expression through blockade of RelA/p65 activity in leiomyoma smooth muscle cells.Fertility and sterility · 2020Article
- Phthalate Exposures and MicroRNA Expression in Uterine Fibroids: The FORGE Study.Epigenetics insights · 2020Article
- Liquid Biopsy as a Tool for Differentiation of Leiomyomas and Sarcomas of Corpus Uteri.International journal of molecular sciences · 2019Review
- MicroRNA 21a-5p overexpression impacts mediators of extracellular matrix formation in uterine leiomyoma.Reproductive biology and endocrinology : RB&E · 2018Article
- Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis.Scientific reports · 2017Article
- microRNAs and the adolescent brain: Filling the knowledge gap.Neuroscience and biobehavioral reviews · 2016Review
- Global Transcriptome Abnormalities of the Eutopic Endometrium From Women With Adenomyosis.Reproductive sciences (Thousand Oaks, Calif.) · 2016Article
- Decreased expression of microRNA-29 family in leiomyoma contributes to increased major fibrillar collagen production.Fertility and sterility · 2016Article
- MicroRNA-15b regulates reversion-inducing cysteine-rich protein with Kazal motifs (RECK) expression in human uterine leiomyoma.Reproductive biology and endocrinology : RB&E · 2016Article
- MicroRNA-206 functions as a tumor suppressor in colorectal cancer by targeting FMNL2.Journal of cancer research and clinical oncology · 2016Article
- Non-coding RNAs in Uterine Development, Function and Disease.Advances in experimental medicine and biology · 2016Review
- miRNAs regulated by estrogens, tamoxifen, and endocrine disruptors and their downstream gene targets.Molecular and cellular endocrinology · 2015Review
- Retracted: Differential expression of microRNAs in myometrium and leiomyomas and regulation by ovarian steroids.Journal of cellular and molecular medicine · 2015Article
- MicroRNA-23a participates in estrogen deficiency induced gap junction remodeling of rats by targeting GJA1.International journal of biological sciences · 2015Article
- 5-Hydroxymethylcytosine promotes proliferation of human uterine leiomyoma: a biological link to a new epigenetic modification in benign tumors.The Journal of clinical endocrinology and metabolism · 2014Article
- Integrated analysis of long noncoding RNAs and mRNAs reveals their potential roles in the pathogenesis of uterine leiomyomas.Oncotarget · 2014Article
Corrections and comments
- Retraction · 2015-09-28Falsification/Fabrication of Data · Investigation by Company/Institution · · Nasser Chegini has finding of misconduct: https://ori.hhs.gov/content/case-summary-chegini-nasser
- Commented on by
- Retracted
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Given the emerging roles of microRNAs (miRNAs) as key regulator of mRNA stability we assessed their expression profile in paired myometrium and leiomyoma, their isolated smooth muscle cells (MSMC and LSMC), a spontaneously transformed leiomyoma smooth muscle cells (T-LSMC) and SK-LMS-1, a leiomyosarcoma cell line using microarray and real time PCR. Based on global normalization of expression values of 385 miRNAs and statistical analysis (anova), 91 miRNAs were expressed above the threshold levels in myometrium, with a progressive decline in numbers in leiomyomas, MSMC, LSMC, T-LSMC and SK-LMS-1 (P<0.05). We selected and validated the expression of miR-20a, miR-21, miR-26a, miR-18a, miR-206, miR-181a and miR-142-5p and found their differential expression in tissue and cell-specific manners (P<0.05). Treatments of MSMC and LSMC with 17beta estradiol and medroxyprogesterone acetate (10(-8)M), or ICI-182780 and RU-486 (10(-6)M) resulted in differential regulation of these miRNAs (P<0.05). In conclusion, the expression of a number of miRNAs in myometrium and leiomyoma with their progressive aberrant from normal MSMC into LSMC, transformed and cancerous stage, suggests that miRNAs and their regulation by ovarian steroids play a key role in pathogenesis of leiomyoma through gene expression stability.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.