ArticleThe Plant journal : for cell and molecular biology2008
Inactivation of the UGPase1 gene causes genic male sterility and endosperm chalkiness in rice (Oryza sativa L.).
Article in The Plant journal : for cell and molecular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 113 citations in OpenAlex.
- Natural Variation and Expression of OsCFF1 Affect the Formation of Rice Chalkiness.Rice (New York, N.Y.) · 2026Article
- Larix gmelinii UGPase enhances vegetative growth in transgenic poplar through an HYH-mediated positive feedback loop.Plant cell reports · 2026Article
- Decoding heat-induced chalkiness in rice: molecular mechanisms, genetic networks, and mitigation strategies for climate resilience.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Review
- Regulatory factors of starch metabolism in cereal endosperm.Plant molecular biology · 2026Review
- Molecular Mechanisms of Grain Chalkiness Variation in Rice Panicles.Plants (Basel, Switzerland) · 2025Article
- Structure and Expression Analysis ofInternational journal of molecular sciences · 2023Article
- OverexpressingPhysiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
- Meta-QTL and haplo-pheno analysis reveal superior haplotype combinations associated with low grain chalkiness under high temperature in rice.Frontiers in plant science · 2023Article
- Exploration of Sugar and Starch Metabolic Pathway Crucial for Pollen Fertility in Rice.International journal of molecular sciences · 2022Review
- Integrative Analysis of Transcriptomic and Proteomic Changes Related to Cytoplasmic Male Sterility in Spring Stem Mustard (International journal of molecular sciences · 2022Article
- RiceFrontiers in plant science · 2022Article
- Homology-based identification of candidate genes for male sterility editing in upland cotton (Frontiers in plant science · 2022Review
- Fine Mapping of Two Major Quantitative Trait Loci for Rice Chalkiness With High Temperature-Enhanced Additive Effects.Frontiers in plant science · 2022Article
- UDP-glucose pyrophosphorylase: genome-wide identification, expression and functional analyses inPeerJ · 2022Article
- Dynamic formation and transcriptional regulation mediated by phytohormones during chalkiness formation in rice.BMC plant biology · 2021Article
- Dissecting the Seed Maturation and Germination Processes in the Non-OrthodoxInternational journal of molecular sciences · 2020Article
- Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases.Acta neuropathologica · 2020Article
- The DROOPING LEAF (DR) gene encoding GDSL esterase is involved in silica deposition in rice (Oryza sativa L.).PloS one · 2020Article
- Dissecting the genome-wide genetic variants of milling and appearance quality traits in rice.Journal of experimental botany · 2019Article
- Generating Photoperiod-Sensitive Genic Male Sterile Rice Lines with CRISPR/Cas9.Methods in molecular biology (Clifton, N.J.) · 2019Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A rice genic male-sterility gene ms-h is recessive and has a pleiotropic effect on the chalky endosperm. After fine mapping, nucleotide sequencing analysis of the ms-h gene revealed a single nucleotide substitution at the 3'-splice junction of the 14th intron of the UDP-glucose pyrophosphorylase 1 (UGPase1; EC2.7.7.9) gene, which causes the expression of two mature transcripts with abnormal sizes caused by the aberrant splicing. An in vitro functional assay showed that both proteins encoded by the two abnormal transcripts have no UGPase activity. The suppression of UGPase by the introduction of a UGPase1-RNAi construct in wild-type plants nearly eliminated seed set because of the male defect, with developmental retardation similar to the ms-h mutant phenotype, whereas overexpression of UGPase1 in ms-h mutant plants restored male fertility and the transformants produced T(1) seeds that segregated into normal and chalky endosperms. In addition, both phenotypes were co-segregated with the UGPase1 transgene in segregating T(1) plants, which demonstrates that UGPase1 has functional roles in both male sterility and the development of a chalky endosperm. Our results suggest that UGPase1 plays a key role in pollen development as well as seed carbohydrate metabolism.
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