ReviewCell proliferation2008
Parthenotes as a source of embryonic stem cells.
Review in Cell proliferation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 82 citations in OpenAlex.
- Sperm-carried IGF2: towards the discovery of a spark contributing to embryo growth and development.Molecular human reproduction · 2024Article
- Generation of blastoids from human parthenogenetic stem cells.Life medicine · 2023Article
- Article
- Genetic Manipulation of the Equine Oocyte and Embryo.Journal of equine veterinary science · 2021Review
- Parthenogenetic bovine embryos secrete type I interferon capable of stimulatingAnimal reproduction · 2018Article
- Stem cells in regenerative medicine - from laboratory to clinical application - the eye.Central-European journal of immunology · 2017Review
- Parthenogenesis and Human Assisted Reproduction.Stem cells international · 2016Review
- Inducing human parthenogenetic embryonic stem cells into islet‑like clusters.Molecular medicine reports · 2014Article
- Sourcing human embryos for embryonic stem cell lines: problems & perspectives.The Indian journal of medical research · 2014Review
- Pluripotent stem cell derived cardiomyocytes for cardiac repair.Current treatment options in cardiovascular medicine · 2014Article
- Article
- Article
- Parthenogenetic stem cells for tissue-engineered heart repair.The Journal of clinical investigation · 2013Article
- Centrosome amplification and chromosomal instability in human and animal parthenogenetic cell lines.Stem cell reviews and reports · 2012Article
- Altered cell cycle gene expression and apoptosis in post-implantation dog parthenotes.PloS one · 2012Article
- Transcriptome profiling of rabbit parthenogenetic blastocysts developed under in vivo conditions.PloS one · 2012Article
- Quantitative proteomics analysis of parthenogenetically induced pluripotent stem cells.Protein & cell · 2011Article
- From embryonic stem cells to iPS - an ethical perspective.Cell proliferation · 2011Article
- Article
- Cell therapy for the treatment of coronary heart disease: a critical appraisal.Nature reviews. Cardiology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The derivation and study of human embryonic stem cell lines, despite their potential therapeutic usefulness, raise considerable ethical, religious, legal and political concerns because it inevitably leads to the destruction of viable embryos. In an attempt to bridge the division between ethical questions and potential scientific and medical benefits, considerable efforts have been devoted to the search for alternative sources of pluripotent cell lines. In this review we discuss the use of artificial parthenogenesis as a way to create entities, called parthenotes, that may represent an alternative ethical source for pluripotent cell lines. We describe the biological differences between parthenotes and embryos, in order to provide a rationale for the discussion on whether their use can be acceptable as a source of stem cells. We present data derived from animal models on the extent parthenogenetic stem cells are similar to biparental cell lines and discuss these aspects in the context of their extension to the human species. Finally, we present experiments recently carried out in our laboratory that allowed us to generate human parthenotes through artificial activation of human oocytes and to use them as a source for the derivation of parthenogenetic pluripotent cell lines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.