ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2008
An ionotropic GABA receptor in cultured mushroom body Kenyon cells of the honeybee and its modulation by intracellular calcium.
Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 26 citations in OpenAlex.
- Heterogeneous expression of GABA receptor-like subunits LCCH3 and GRD reveals functional diversity of GABA receptors in the honeybee Apis mellifera.British journal of pharmacology · 2020Article
- RNAi and Antiviral Defense in the Honey Bee.Journal of immunology research · 2015Review
- Honeybee Kenyon cells are regulated by a tonic GABA receptor conductance.Journal of neurophysiology · 2014Article
- Effect of GABAergic inhibition on odorant concentration coding in mushroom body intrinsic neurons of the honeybee.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2014Article
- Identification and functional analysis of the S-layer protein SplA of Paenibacillus larvae, the causative agent of American Foulbrood of honey bees.PLoS pathogens · 2012Article
- Acute ethanol ingestion impairs appetitive olfactory learning and odor discrimination in the honey bee.Neurobiology of learning and memory · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
GABAergic inhibitory transmission is very abundant within the insect brain. We, therefore, studied the functional properties of the ionotropic GABA receptor of honeybee mushroom body Kenyon cells in vitro. GABA applications elicit rapidly activating and desensitizing currents, which are concentration-dependent between 10 and 500 microM. The mean peak amplitude induced by 500 microM GABA at a holding potential of -110 mV is -1.55 +/- 0.23 nA (SEM, n = 29). The GABA-induced current is mediated by Cl(-) ions because (1) the reversal potential of the GABA-induced current of -40.6 mV is very close to the calculated Nernst potential of chloride (-44.8 mV). (2) With equimolar chloride concentrations the reversal potential shifted to about 0 mV. GABA or muscimol are equally efficient channel agonists, whereas CACA is a partial agonist. Picrotoxin or philanthotoxin (100 microM) completely and reversibly block the GABA-induced current, bicuculline (100 microM) has no effect. Elevating the intracellular Ca(2+) concentration increases the GABA current amplitude. This modulatory effect is blocked by the kinase blocker K 252a, but not by blockers of CaMkinaseII (KN-93), PKC (bisindolylmaleimide) or PKA (KT 5720). We conclude that Kenyon cells express functional GABA receptors whose properties support an inhibitory role of GABAergic transmission.
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