Trial reportEuropean journal of clinical pharmacology2008
Early pharmacokinetics of nasal fentanyl: is there a significant arterio-venous difference?
Trial report in European journal of clinical pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 52 citations in OpenAlex.
- Optimal Volume of Administration of Intranasal Midazolam in Children: A Randomized Clinical Trial.Annals of emergency medicine · 2017Trial
- Pharmacokinetic Characterisation and Comparison of Bioavailability of Intranasal Fentanyl, Transmucosal, and Intravenous Administration through a Three-Way Crossover Study in 24 Healthy Volunteers.Pain research & managementTrial
- Acute pain management in older adults presenting to the emergency department: a clinical review.Singapore medical journal · 2026Review
- Intranasal Fentanyl for Acute Pain Management in Children, Adults and Elderly Patients in the Prehospital Emergency Service and in the Emergency Department: A Systematic Review.Journal of clinical medicine · 2023Review
- Effect of Fentanyl Infusion on Heart Rate Variability and Anaesthetic Requirements in Isoflurane-Anaesthetized Horses.Animals : an open access journal from MDPI · 2021Article
- Population pharmacokinetic model of subcutaneous fentanyl in older acute care patients.European journal of clinical pharmacology · 2021Article
- Sampling Site Has a Critical Impact on Physiologically Based Pharmacokinetic Modeling.The Journal of pharmacology and experimental therapeutics · 2020Article
- Efficacy and cost savings with the use of a minimal sedation / anxiolysis protocol for intra-articular corticosteroid injections in children with juvenile idiopathic arthritis: a retrospective review of prospectively collected data.Pediatric rheumatology online journal · 2019Article
- Pharmacodynamics and arteriovenous difference of intravenous naloxone in healthy volunteers exposed to remifentanil.European journal of clinical pharmacology · 2018Article
- Review
- Intranasal Opioid Administration in Rhesus Monkeys: PET Imaging and Antinociception.The Journal of pharmacology and experimental therapeutics · 2016Article
- Article
- Pharmacokinetics of non-intravenous formulations of fentanyl.Clinical pharmacokinetics · 2013Review
- A physiologically-based recirculatory meta-model for nasal fentanyl in man.Journal of pharmacokinetics and pharmacodynamics · 2012Article
- Can finger-prick sampling replace venous sampling to determine the pharmacokinetic profile of oral paracetamol?British journal of clinical pharmacology · 2010Article
- Distribution of fentanyl in the placental intervillous space and in the different maternal and fetal compartments in term pregnant women.European journal of clinical pharmacology · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe have investigated the arterio-venous difference in the pharmacokinetics of 50 microg fentanyl during the first hour following nasal administration and documented its tolerability in opioid-naïve middle-aged to elderly patients.
methodsTwelve male patients (range in age 47-84 years) scheduled for transurethral resection of the prostate gland received a 100-microl dose of 50 microg fentanyl base as a fentanyl citrate formulation in one nostril. Simultaneous arterial and venous blood samples for analyses of fentanyl were drawn at baseline and at 1, 3, 5, 7, 9, 13, 15, 20, 25, 35, 45 and 60 min after drug administration. Vital signs, sedation and symptoms of local irritation were recorded.
resultsThe arterial C(max) (maximum serum concentration) of 0.83 ng/ml was nearly twofold higher than the venous C(max) of 0.47 ng/ml, and the arterial T(max) (time to maximum serum concentration) of 7.0 min was about 5 min shorter than the venous T(max) of 11.6 min. The arterial AUC(0-60) (area under the curve from 0 to 60 min after administration) of 21 min*ng/ml was approximately 30% larger than the venous AUC(0-60) of 15 min*ng/ml (all p values < or = 0.005). Venous T(max) and C(max) did not predict the corresponding arterial values. No significant adverse events were observed.
conclusionA significant arterio-venous difference was present after intranasal administration of fentanyl. The short arterial T(max) complies with its rapid onset of action. The use of venous concentrations for the prediction of onset time of analgesia should be discouraged. A 50-microg dose of nasal fentanyl was well tolerated by opioid-naïve middle-aged to elderly male patients.
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