ArticlePsychopharmacology2008
Juvenile rats in the forced-swim test model the human response to antidepressant treatment for pediatric depression.
Article in Psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Effects of chronic fluoxetine treatment on anxiety- and depressive-like behaviors in adolescent rodents - systematic review and meta-analysis.Pharmacological reports : PR · 2022Pooled it
- Comparative Evaluation of Antidepressant and Anxiolytic Effects of Escitalopram, Crocin, and their Combination in Rats.Advanced biomedical research · 2024Article
- Chronic SSRI Treatment, but Not Norepinephrine Reuptake Inhibitor Treatment, Increases Neurogenesis in Juvenile Rats.International journal of molecular sciences · 2022Article
- The Combination of Galanin (1-15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression.Biomedicines · 2022Article
- Galanin(1-15) Potentiates the Antidepressant-like Effects Induced by Escitalopram in a Rat Model of Depression.International journal of molecular sciences · 2021Article
- Nicotine treatment buffers negative behavioral consequences induced by exposure to physical and emotional stress in adolescent male mice.Psychopharmacology · 2020Article
- Article
- Intracerebroventricular Ghrelin Administration Increases Depressive-Like Behavior in Male Juvenile Rats.Frontiers in behavioral neuroscience · 2019Article
- Targeting Serotonin Transporters in the Treatment of Juvenile and Adolescent Depression.Frontiers in neuroscience · 2019Article
- Repeated Forced Swim Exacerbates Methamphetamine-Induced Neurotoxicity: Neuroprotective Effects of Nanowired Delivery of 5-HT3-Receptor Antagonist Ondansetron.Molecular neurobiology · 2018Article
- Ontogeny of Norepinephrine Transporter Expression and Antidepressant-Like Response to Desipramine in Wild-Type and Serotonin Transporter Mutant Mice.The Journal of pharmacology and experimental therapeutics · 2017Article
- The Effect of Congenital and Postnatal Hypothyroidism on Depression-Like Behaviors in Juvenile Rats.Journal of clinical research in pediatric endocrinology · 2016Article
- Ontogeny of SERT Expression and Antidepressant-like Response to Escitalopram in Wild-Type and SERT Mutant Mice.The Journal of pharmacology and experimental therapeutics · 2016Article
- Antidepressant-like effects and basal immobility depend on age and serotonin transporter genotype.Genes, brain, and behavior · 2015Article
- Robust presynaptic serotonin 5-HT(1B) receptor inhibition of the striatonigral output and its sensitization by chronic fluoxetine treatment.Journal of neurophysiology · 2015Article
- Dietary DHA during development affects depression-like behaviors and biomarkers that emerge after puberty in adolescent rats.Journal of lipid research · 2015Article
- Fluoxetine exposure during adolescence alters responses to aversive stimuli in adulthood.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Treadmill exercise exerts ameliorating effect on isolation-induced depression via neuronal activation.Journal of exercise rehabilitation · 2013Article
- Antidepressant-like drug effects in juvenile and adolescent mice in the tail suspension test: Relationship with hippocampal serotonin and norepinephrine transporter expression and function.Frontiers in pharmacology · 2013Article
- Effects of periadolescent fluoxetine and paroxetine on elevated plus-maze, acoustic startle, and swimming immobility in rats while on and off-drug.Behavioral and brain functions : BBF · 2011Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleCurrently, there are limited treatment options for major depressive disorder in children and adolescents compared to the options available for adults. Many effective treatments used for adult depression, such as the tricyclic antidepressants, lack efficacy when given to children and adolescents.
objectiveTo more quickly identify compounds that could be effective for treating childhood and adolescent depression, a reliable preclinical animal behavioral test of antidepressant efficacy for pediatric depression is needed. The forced-swim test (FST) with juvenile rats was assessed to determine its reliability as a predictive model for pediatric depression. MATERIALS AND
methodsWe adapted procedures from the adult FST to test 21-day-old juvenile rats. The 21-day-old animals were treated with three classes of antidepressant drugs before being assessed in the FST: the selective serotonin reuptake inhibitors escitalopram or fluoxetine; the tricyclic antidepressants desipramine or imipramine; and the monoamine oxidase inhibitor tranylcypromine.
resultsThe 21-day-old rats showed dose-dependent changes in behaviors similar to those seen in adults when treated with escitalopram or fluoxetine. Tranylcypromine also decreased immobility in 21-day-old rats. Treatment with desipramine or imipramine, however, was not effective at reducing immobility in the 21-day-old rats.
conclusionsThe juvenile FST accurately predicts the efficacy of selective serotonin reuptake inhibitors and the lack of efficacy of tricyclic antidepressants in the treatment of depression in children and adolescents. This suggests that the FST using 21-day-old rats may help to develop better treatments for childhood and adolescent depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.