ArticleIntensive care medicine2008
Aging increases the susceptibility to injurious mechanical ventilation.
Article in Intensive care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Age-dependent ventilator-induced lung injury: Mathematical modeling, experimental data, and statistical analysis.PLoS computational biology · 2024Article
- Unphysiological lung strain promotes ventilation-induced lung injury via activation of the PECAM-1/Src/STAT3 signaling pathway.Frontiers in pharmacology · 2024Article
- S1P lyase inhibition prevents lung injury following high pressure-controlled mechanical ventilation in aging mice.Experimental gerontology · 2023Article
- Elderly Patients and Management in Intensive Care Units (ICU): Clinical Challenges.Clinical interventions in aging · 2023Review
- Angiotensin-converting enzyme 2 (ACE2) expression increases with age in patients requiring mechanical ventilation.PloS one · 2021Article
- The Impact of Aging in Acute Respiratory Distress Syndrome: A Clinical and Mechanistic Overview.Frontiers in medicine · 2020Review
- Inflammation and Monocyte Recruitment due to Aging and Mechanical Stretch in Alveolar Epithelium are Inhibited by the Molecular Chaperone 4-phenylbutyrate.Cellular and molecular bioengineering · 2018Article
- Caring for the critically ill patients over 80: a narrative review.Annals of intensive care · 2018Review
- Differential Regulation of the Extracellular Cysteine/Cystine Redox State (EhCySS) by Lung Fibroblasts from Young and Old Mice.Oxidative medicine and cellular longevity · 2016Article
- Lung fibroblasts accelerate wound closure in human alveolar epithelial cells through hepatocyte growth factor/c-Met signaling.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Influence of hyperoxia and mechanical ventilation in lung inflammation and diaphragm function in aged versus adult rats.Inflammation · 2014Article
- Susceptibility to ventilator induced lung injury is increased in senescent rats.Critical care (London, England) · 2013Article
- Predisposition for disrepair in the aged lung.The American journal of the medical sciences · 2012Article
- Development of demographics and outcome of very old critically ill patients admitted to intensive care units.Intensive care medicine · 2012Article
- Effect of aging on cellular mechanotransduction.Ageing research reviews · 2011Review
- Toward an integrated research agenda for critical illness in aging.American journal of respiratory and critical care medicine · 2010Article
- Role of free radicals in vascular dysfunction induced by high tidal volume ventilation.Intensive care medicine · 2009Article
- Year in review in Intensive Care Medicine, 2008: II. Experimental, acute respiratory failure and ARDS, mechanical ventilation and endotracheal intubation.Intensive care medicine · 2009Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo test the hypothesis that aging increases the susceptibility to organ dysfunction and systemic inflammation induced by injurious mechanical ventilation. DESIGN AND
settingExperimental study in an animal model of ventilator-induced lung injury in the animal research laboratory in a university hospital.
methodsYoung (3-4 months old) and old (22-24 months old) anesthetized Wistar rats were ventilated for 60 min with a protective lung strategy (VT=9 ml/kg and PEEP=5 cm H2O, control) or with an injurious strategy (VT=35 ml/kg and PEEP=0 cm H2O, over-ventilated; n=6 for each group). MEASUREMENTS AND
resultsMean arterial pressure and airway pressures (PAW) were monitored. Arterial blood gases and serum AST, ALT, lactate, and IL-6 were measured. Vascular rings from the thoracic aorta were mounted in organ baths for isometric tension recording. We studied relaxations induced by acetylcholine (10 nM-10 microM) in norepinephrine-precontracted rings, and contractions induced by norepinephrine (1 nM-10 microM) in resting vessels. Lungs were examined by light microscopy. Injurious ventilation in young rats was associated with hypoxemia, lactic metabolic acidosis, increased serum AST, hypotension, impairment in norepinephrine and acetylcholine-induced vascular responses ex vivo and hyaline membrane formation. The high-VT induced hypotension, increase in mean PAW, AST, and IL-6, and the impairment in acetylcholine-induced responses were significantly more marked in aged than in young rats.
conclusionsElderly rats showed increased susceptibility to injurious mechanical ventilation-induced pulmonary injury, vascular dysfunction, and systemic inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.