Evidence map›Paper›PMID 18180765›Full record

ArticleMolecular psychiatry2008

A collaborative knowledge base for cognitive phenomics.

F W Sabb, C E Bearden, D C Glahn, D S Parker, N Freimer, R M Bilder

Abstract read
In one paragraph

Article in Molecular psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Trial
  2. Neurostimulation to Improve Cognitive Flexibility.Current opinion in behavioral sciences · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Women are more sensitive than men to prior trial events on the Stop-signal task.British journal of psychology (London, England : 1953) · 2014
    Article
  11. Review
  12. Article
  13. Article
  14. Genetic architecture of declarative memory: implications for complex illnesses.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2012
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Neuropsychology 3.0: evidence-based science and practice.Journal of the International Neuropsychological Society : JINS · 2011
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

F W SabbSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90095-1759, USA.
C E Bearden
D C Glahn
D S Parker
N Freimer
R M Bilder

Funding

PSYCHOLOGICAL RESEARCH ON SCHIZOPHRENIC CONDITIONST32MH014584 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NUECHTERLEIN, KEITH H · 1985 to 2009
$3.0M
COGNITIVE PHENOTYPING:NEUROPSYCHIATRIC THERAPEUTICS(RMI)P20RR020750 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BILDER, ROBERT M · 2004 to 2006
$1.8M
Response Inhibition and Dopamine Neurotransmission (RI) (4 of 8)RL1DA024853 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONDON, EDYTHE DANICK · 2007 to 2011
$1.7M
Identification of endophenotypes for bipolar disorderK23MH074644 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E · 2005 to 2009
$808k
NCRR NIH HHS P20 RR020750NIDA NIH HHS RL1 DA024853NIMH NIH HHS K23 MH074644NIMH NIH HHS T32 MH014584
6 · The paper itself

Abstract

The human genome project has stimulated development of impressive repositories of biological knowledge at the genomic level and new knowledge bases are rapidly being developed in a 'bottom-up' fashion. In contrast, higher-level phenomics knowledge bases are underdeveloped, particularly with respect to the complex neuropsychiatric syndrome, symptom, cognitive, and neural systems phenotypes widely acknowledged as critical to advance molecular psychiatry research. This gap limits informatics strategies that could improve both the mining and representation of relevant knowledge, and help prioritize phenotypes for new research. Most existing structured knowledge bases also engage a limited set of contributors, and thus fail to leverage recent developments in social collaborative knowledge-building. We developed a collaborative annotation database to enable representation and sharing of empirical information about phenotypes important to neuropsychiatric research (www.Phenowiki.org). As a proof of concept, we focused on findings relevant to 'cognitive control', a neurocognitive construct considered important to multiple neuropsychiatric syndromes. Currently this knowledge base tabulates empirical findings about heritabilities and measurement properties of specific cognitive task and rating scale indicators (n=449 observations). It is hoped that this new open resource can serve as a starting point that enables broadly collaborative knowledge-building, and help investigators select and prioritize endophenotypes for translational research.

Indexed as

Cooperative BehaviorDatabases as TopicKnowledge BasesPhenotypeCognitionComputational BiologyDatabase Management SystemsHumans

Identifiers

PMID18180765
PMCPMC3952067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.