ArticleLaboratory investigation; a journal of technical methods and pathology2008
Effect of Helicobacter pylori eradication on gastric carcinogenesis.
Article in Laboratory investigation; a journal of technical methods and pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 61 citations in OpenAlex.
- The hyaluronic acid receptor CD44 coordinates normal and metaplastic gastric epithelial progenitor cell proliferation.The Journal of biological chemistry · 2013Trial
- Identification of Antimicrobial Peptide Variants From Lactobacillus spp. Against H. pylori-Mediated Gastric Cancer: An In-Silico Approach.The Korean journal of helicobacter and upper gastrointestinal research · 2026Article
- Statistical proof ofWorld journal of gastrointestinal surgery · 2022Article
- The Role of Gut Microbiota in Gastrointestinal Tract Cancers.Archivum immunologiae et therapiae experimentalis · 2022Review
- The role of polyamines in gastric cancer.Oncogene · 2021Review
- Article
- Efficacy and Long-Term Safety ofCancers · 2019Review
- Epidemiology ofToxins · 2018Review
- Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models.Disease models & mechanisms · 2017Review
- Interaction between inflammatory mediators and miRNAs in Helicobacter pylori infection.Cellular microbiology · 2016Article
- Genetic Evolution of a Helicobacter pylori Acid-Sensing Histidine Kinase and Gastric Disease.The Journal of infectious diseases · 2016Article
- Characterization of progressive metaplasia in the gastric corpus mucosa of Mongolian gerbils infected with Helicobacter pylori.The Journal of pathology · 2016Article
- Role of Helicobacter pylori in gastric cancer: Updates.World journal of gastrointestinal oncology · 2016Review
- Conifer Green Needle Complex in Patients with Precancerous Gastric Lesions: An Observational Pilot Study.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Menadione induces G2/M arrest in gastric cancer cells by down-regulation of CDC25C and proteasome mediated degradation of CDK1 and cyclin B1.American journal of translational research · 2016Article
- CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation.PLoS pathogens · 2015Article
- Early or late antibiotic intervention prevents Helicobacter pylori-induced gastric cancer in a mouse model.Cancer letters · 2014Article
- Article
- High dietary salt intake exacerbates Helicobacter pylori-induced gastric carcinogenesis.Infection and immunity · 2013Article
- Rodent models of Helicobacter infection, inflammation, and disease.Methods in molecular biology (Clifton, N.J.) · 2012Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic gastritis induced by Helicobacter pylori is the strongest known risk factor for gastric adenocarcinoma, yet the effects of bacterial eradication on carcinogenesis remain unclear. Animal models provide important insights into factors that are involved in gastric carcinogenesis, and we previously utilized such a model to demonstrate that an in vivo-adapted H. pylori strain, 7.13, rapidly and reproducibly induces inflammation-mediated gastric carcinoma. In the current study, we used this bacterial strain as a prototype to define the role of targeted antimicrobial therapy in gastric carcinogenesis. Mongolian gerbils were infected with H. pylori for 4 or 8 weeks, treated with antimicrobial agents or vehicle, and then euthanized at 8 weeks after the completion of therapy. All infected gerbils developed gastritis; however, inflammation was significantly attenuated in animals receiving antimicrobial therapy. Gastric dysplasia or cancer developed in >60% of the gerbils that remained persistently colonized with H. pylori, but in none of the animals treated with antibiotics following 4 weeks of infection. Infection with H. pylori for 8 weeks prior to therapy resulted in an attenuation, but not complete prevention, of pre-malignant and malignant lesions. Similarly, antibiotic therapy initiated at 4, but not 8, weeks after H. pylori challenge significantly reduced expression of the Th1 pro-inflammatory cytokine interferon-gamma within colonized gastric mucosa. These results indicate that treatment of H. pylori in this model decreases the incidence and severity of lesions with carcinogenic potential. The effectiveness of eradication is dependent upon the timing of intervention, providing insights into mechanisms that may regulate the development of malignancies arising within the context of inflammatory states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.