ArticleThe Journal of pharmacology and experimental therapeutics2008
Evidence for the role of mitogen-activated protein kinase signaling pathways in the development of spinal cord injury.
Article in The Journal of pharmacology and experimental therapeutics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Warm acupuncture therapy alleviates neuronal apoptosis after spinal cord injury via inhibition of the ERK signaling pathway.The journal of spinal cord medicine · 2023Article
- Deciphering the Molecular Mechanism of Escin against Neuropathic Pain: A Network Pharmacology Study.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Injection of Cerium Oxide Nanoparticles to Treat Spinal Cord Injury in Rats.Journal of neuropathology and experimental neurology · 2022Article
- Using Network Pharmacology and Animal Experiment to Investigate the Therapeutic Mechanisms of Polydatin against Vincristine-Induced Neuropathic Pain.Mediators of inflammation · 2022Article
- Using Network Pharmacology to Systematically Decipher the Potential Mechanisms of Jisuikang in the Treatment of Spinal Cord Injury.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Diagnostic Markers and Molecular Dysregulation Mechanisms in the Retinal Pigmented Epithelium and Retina of Age-Related Macular Degeneration.Journal of healthcare engineering · 2022Article
- Roles of extra-cellular signal-regulated protein kinase 5 signaling pathway in the development of spinal cord injury.Chinese medical journal · 2019Article
- Ursodeoxycholic Acid Inhibits Inflammatory Responses and Promotes Functional Recovery After Spinal Cord Injury in Rats.Molecular neurobiology · 2019Article
- Fire Needle Acupuncture Regulates Wnt/ERK Multiple Pathways to Promote Neural Stem Cells to Differentiate into Neurons in Rats with Spinal Cord Injury.CNS & neurological disorders drug targets · 2019Article
- MiR-103 alleviates autophagy and apoptosis by regulating SOX2 in LPS-injured PC12 cells and SCI rats.Iranian journal of basic medical sciences · 2018Article
- Role of Caspase-8 and Fas in Cell Death After Spinal Cord Injury.Frontiers in molecular neuroscience · 2018Review
- PPAR-α Modulates the Anti-Inflammatory Effect of Melatonin in the Secondary Events of Spinal Cord Injury.Molecular neurobiology · 2017Article
- Tocotrienol alleviates inflammation and oxidative stress in a rat model of spinal cord injury via suppression of transforming growth factor-β.Experimental and therapeutic medicine · 2017Article
- Temporospatial expression of fibulin-1 after acute spinal cord injury in rats.The journal of spinal cord medicine · 2015Article
- Role of melatonin in traumatic brain injury and spinal cord injury.TheScientificWorldJournal · 2014Review
- MEK inhibition reduces glial scar formation and promotes the recovery of sensorimotor function in rats following spinal cord injury.Experimental and therapeutic medicine · 2014Article
- Inhibition of EGFR/MAPK signaling reduces microglial inflammatory response and the associated secondary damage in rats after spinal cord injury.Journal of neuroinflammation · 2012Article
- Inflammation & apoptosis in spinal cord injury.The Indian journal of medical research · 2012Review
- Pregabalin as a neuroprotector after spinal cord injury in rats: biochemical analysis and effect on glial cells.Journal of Korean medical science · 2011Article
- Involvement of ERK2 in traumatic spinal cord injury.Journal of neurochemistry · 2010Article
Corrections and comments
- Expression of concern
- Expression of concern
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitogen-activated protein kinase (MAPK) signaling pathways involve two closely related MAPKs, known as extracellular signal-regulated kinase (ERK)1 and ERK2. The aim of the present study was to evaluate the contribution of MAPK3/MAPK1 in the secondary damage in experimental spinal cord injury (SCI) in mice. To this purpose, we used 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one (PD98059), which is an inhibitor of MAPK3/MAPK1. Spinal cord trauma was induced by the application of vascular clips (force of 24 g) to the dura via a four-level T5-T8 laminectomy. SCI in mice resulted in severe trauma characterized by edema, neutrophil infiltration, and production of inflammatory mediators, tissue damage, and apoptosis. PD98059 treatment (10 mg/kg i.p.) at 1 and 6 h after the SCI significantly reduced 1) the degree of spinal cord inflammation and tissue injury (histological score), 2) neutrophil infiltration (myeloperoxidase activity), 3) nitrotyrosine formation, 4) proinflammatory cytokines expression, 5) nuclear factor-kappaB activation, 6) phospho-ERK1/2 expression, and 6) apoptosis (terminal deoxynucleotidyl transferase dUTP nick-end labeling staining, Fas ligand, Bax, and Bcl-2 expression). Moreover, PD98059 significantly ameliorated the recovery of limb function (evaluated by motor recovery score) in a dose-dependent manner. Taken together, our results clearly demonstrate that PD98059 treatment reduces the development of inflammation and tissue injury associated with spinal cord trauma.
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