ReviewThe Journal of cell biology2008
The cell biological basis of ciliary disease.
Review in The Journal of cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Analysis from the perspective of cilia: the protective effect of PARP inhibitors on visual function during light-induced damage.International ophthalmology · 2020Pooled it
- A Ciliary Phosphoinositide Pathway Regulates the Dosage of Polycystins in Primary Cilia.Journal of the American Society of Nephrology : JASN · 2026Article
- TRPV4 Channel Modulators as Potential Drug Candidates for Cystic Fibrosis.International journal of molecular sciences · 2024Review
- Emerging principles of primary cilia dynamics in controlling tissue organization and function.The EMBO journal · 2023Review
- Protein quality control machinery supports primary ciliogenesis by eliminating GDP-bound Rab8-family GTPases.iScience · 2023Article
- Loss of RNA-Binding Protein HuR Leads to Defective Ependymal Cells and Hydrocephalus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
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- Article
- Functional analysis by minigene assay of putative splicing variants found in Bardet-Biedl syndrome patients.Journal of cellular and molecular medicine · 2017Article
- Article
- Phosphorylation-dependent Akt-Inversin interaction at the basal body of primary cilia.The EMBO journal · 2016Article
- Crescerin uses a TOG domain array to regulate microtubules in the primary cilium.Molecular biology of the cell · 2015Article
- miR-34/449 control apical actin network formation during multiciliogenesis through small GTPase pathways.Nature communications · 2015Article
- Dynein-deficient flagella respond to increased viscosity with contrasting changes in power and recovery strokes.Cytoskeleton (Hoboken, N.J.) · 2015Article
- Article
- A dual role for planar cell polarity genes in ciliated cells.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Casein kinase 1δ functions at the centrosome and Golgi to promote ciliogenesis.Molecular biology of the cell · 2014Article
- Centrin 2 is required for mouse olfactory ciliary trafficking and development of ependymal cilia planar polarity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The genetic relationship between handedness and neurodevelopmental disorders.Trends in molecular medicine · 2014Review
- The primary cilium: guardian of organ development and homeostasis.Organogenesis · 2014Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Defects in cilia cause a broad spectrum of human diseases known collectively as the ciliopathies. Although all ciliopathies arise from defective cilia, the range of symptoms can vary significantly, and only a small subset of the possible ciliary disease symptoms may be present in any given syndrome. This complexity is puzzling until one realizes that the cilia are themselves exceedingly complex machines that perform multiple functions simultaneously, such that breaking one piece of the machine can leave some functions intact while destroying others. The clinical complexity of the ciliopathies can therefore only be understood in light of the basic cell biology of the cilia themselves, which I will discuss from the viewpoint of cell biological studies in model organisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.