ArticleAntimicrobial agents and chemotherapy2008
Increase of virulence and its phenotypic traits in drug-resistant strains of Candida albicans.
Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Combination antifungal therapy against resistant C. albicans: efficacy and immune response in mice.AMB Express · 2026Article
- Clinical Characteristics and Mortality Risk Factors ofAnnals of laboratory medicine · 2026Article
- Carvacrol Reduces Virulence Traits inMicroorganisms · 2026Article
- Pan-omics-based characterization and prediction of highly multidrug-adapted strains from an outbreak fungal species complex.Innovation (Cambridge (Mass.)) · 2024Article
- Identification of Virulence Factors in Isolates ofMicroorganisms · 2024Article
- Hyperexpression of CDRs and HWP1 genes negatively impacts on Candida albicans virulence.PloS one · 2021Article
- Evaluation of Biofilm Formation inMicroorganisms · 2020Article
- Pathways That Synthesize Phosphatidylethanolamine Impact Candida albicans Hyphal Length and Cell Wall Composition through Transcriptional and Posttranscriptional Mechanisms.Infection and immunity · 2020Article
- A Potential Antifungal Effect of Chitosan AgainstFrontiers in microbiology · 2019Article
- Importance ofFrontiers in cellular and infection microbiology · 2019Article
- Deletion ofAntimicrobial agents and chemotherapy · 2018Article
- In Vivo Paracoccidioides sp. Biofilm on Vascular Prosthesis.Mycopathologia · 2017Article
- The development of fluconazole resistance in Candida albicans - an example of microevolution of a fungal pathogen.Journal of microbiology (Seoul, Korea) · 2016Review
- Synergistic Effects and Mechanisms of Budesonide in Combination with Fluconazole against Resistant Candida albicans.PloS one · 2016Article
- Quercetin sensitizes fluconazole-resistant candida albicans to induce apoptotic cell death by modulating quorum sensing.Antimicrobial agents and chemotherapy · 2015Article
- Candida albicans Biofilms and Human Disease.Annual review of microbiology · 2015Review
- Identification, typing, antifungal resistance profile, and biofilm formation of Candida albicans isolates from Lebanese hospital patients.BioMed research international · 2014Article
- Glutathione metabolism in Candida albicans resistant strains to fluconazole and micafungin.PloS one · 2014Article
- Fluconazole assists berberine to kill fluconazole-resistant Candida albicans.Antimicrobial agents and chemotherapy · 2013Article
- Epidemiological characteristics of Candida species colonizing oral and rectal sites of Jordanian infants.BMC pediatrics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is concern about the rise of antifungal drug resistance, but little is known about comparative biological properties and pathogenicity of drug-resistant strains. We generated fluconazole (FLC; CO23 RFLC)- or micafungin (FK; CO23 RFK)-resistant strains of Candida albicans by treating a FLC- and FK-susceptible strain of this fungus (CO23 S) with stepwise-increasing concentrations of either drug. Molecular analyses showed that CO23 RFLC had acquired markedly increased expression of the drug-resistance efflux pump encoded by the MDR1 gene, whereas CO23 RFK had a homozygous mutation in the FSK1 gene. These genetic modifications did not alter to any extent the growth capacity of the drug-resistant strains in vitro, either at 28 degrees C or at 37 degrees C, but markedly increased their experimental pathogenicity in a systemic mouse infection model, as assessed by the overall mortality and target organ invasion. Interestingly, no apparent increase in the vaginopathic potential of the strains was observed with an estrogen-dependent rat vaginal infection. The increased pathogenicity of drug-resistant strains for systemic infection was associated with a number of biochemical and physiological changes, including (i) marked cellular alterations associated with a different expression and content of major cell wall polysaccharides, (ii) more rapid and extensive hypha formation in both liquid and solid media, and (iii) increased adherence to plastic and a propensity for biofilm formation. Overall, our data demonstrate that experimentally induced resistance to antifungal drugs, irrespective of drug family, can substantially divert C. albicans biology, affecting in particular biological properties of potential relevance for deep-seated candidiasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.