ArticleMolecular and cellular biology2008
Histone H3 tails containing dimethylated lysine and adjacent phosphorylated serine modifications adopt a specific conformation during mitosis and meiosis.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Histone Modifications in the Cell Cycle ofEpigenomes · 2026Review
- Growth factor-induced activation of MSK2 leads to phosphorylation of H3K9me2S10 and corresponding changes in gene expression.Science advances · 2024Article
- Epigenetic markers in the embryonal germ cell development and spermatogenesis.Basic and clinical andrology · 2023Review
- Article
- H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis.eLife · 2019Article
- The effect of epigenetic modifications on the secondary structures and possible binding positions of the N-terminal tail of histone H3 in the nucleosome: a computational study.Journal of molecular modeling · 2017Article
- Quantitative proteomics reveals a role for epigenetic reprogramming during human monocyte differentiation.Molecular & cellular proteomics : MCP · 2015Article
- Initial characterization of histone H3 serine 10 O-acetylation.Epigenetics · 2013Article
- Differential cellular and molecular effects of butyrate and trichostatin a on vascular smooth muscle cells.Pharmaceuticals (Basel, Switzerland) · 2012Article
- Structural role of RKS motifs in chromatin interactions: a molecular dynamics study of HP1 bound to a variably modified histone tail.Biophysical journal · 2012Article
- H3K79me3T80ph is a Novel Histone Dual Modification and a Mitotic Indicator in Melanoma.Journal of skin cancer · 2012Article
- Structure and mechanisms of lysine methylation recognition by the chromodomain in gene transcription.Biochemistry · 2011Review
- Butyrate, an HDAC inhibitor, stimulates interplay between different posttranslational modifications of histone H3 and differently alters G1-specific cell cycle proteins in vascular smooth muscle cells.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2010Article
- Paternal exposure to cyclophosphamide affects the progression of sperm chromatin decondensation and activates a DNA damage response in the prepronuclear rat zygote.Biology of reproduction · 2010Article
- SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.Journal of cellular physiology · 2010Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Condensation of chromatin, mediated in part by posttranslational modifications of histones, is essential for cell division during mitosis. Histone H3 tails are dimethylated on lysine (Kme2) and become phosphorylated on serine (Sp) residues during mitosis. We have explored the possibility that these double modifications are involved in the establishment of H3 tail conformations during the cell cycle. Here we describe a specific chromatin conformation occurring at Kme2 and adjacently phosphorylated S of H3 tails upon formation of a hydrogen bond. This conformation appears exclusively between early prophase and early anaphase of the mitosis, when chromatin condensation is highest. Moreover, we observed that the conformed H3Kme2Sp tail is present at the diplotene and metaphase stages in spermatocytes and oocytes. Our data together with results obtained by cryoelectron microscopy suggest that the conformation of Kme2Sp-modified H3 tails changes during mitosis and meiosis. This is supported by biostructural modeling of a modified histone H3 tail bound by an antibody, indicating that Kme2Sp-modified H3 tails can adopt at least two different conformations. Thus, the H3K9me2S10p and the H3K27me2S28p sites are involved in the acquisition of specific chromatin conformations during chromatin condensation for cell division.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.