ArticleMolecular genetics and metabolism2008
Mammalian SNM1 is required for genome stability.
Article in Molecular genetics and metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Structure and Function of SNM1 Family Nucleases.Advances in experimental medicine and biology · 2023Review
- Probing the Binding Requirements of Modified Nucleosides with the DNA Nuclease SNM1A.Molecules (Basel, Switzerland) · 2021Article
- The SNM1A DNA repair nuclease.DNA repair · 2020Review
- Ubiquitylation at the Fork: Making and Breaking Chains to Complete DNA Replication.International journal of molecular sciences · 2018Review
- Large-scale genotyping identifies 41 new loci associated with breast cancer risk.Nature genetics · 2013Article
- A DNA repair pathway-focused score for prediction of outcomes in ovarian cancer treated with platinum-based chemotherapy.Journal of the National Cancer Institute · 2012Article
- Components of a Fanconi-like pathway control Pso2-independent DNA interstrand crosslink repair in yeast.PLoS genetics · 2012Article
- Orchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair.Cell cycle (Georgetown, Tex.) · 2011Review
- Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair.Genes & development · 2011Article
- Snm1B/Apollo functions in the Fanconi anemia pathway in response to DNA interstrand crosslinks.Human molecular genetics · 2011Article
- RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger.The Journal of biological chemistry · 2010Article
- The multifunctional SNM1 gene family: not just nucleases.Future oncology (London, England) · 2010Review
- DNA interstrand crosslink repair in mammalian cells: step by step.Critical reviews in biochemistry and molecular biology · 2010Review
- The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans.The EMBO journal · 2009Article
- DNA interstrand crosslink repair in mammalian cells.Journal of cellular physiology · 2009Review
- Loss of homologous recombination or non-homologous end-joining leads to radial formation following DNA interstrand crosslink damage.Cytogenetic and genome research · 2008Article
- ERCC1 is required for FANCD2 focus formation.Molecular genetics and metabolismArticle
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
The protein encoded by SNM1 in Saccharomyces cerevisiae has been shown to act specifically in DNA interstrand crosslinks (ICL) repair. There are five mammalian homologs of SNM1, including Artemis, which is involved in V(D)J recombination. Cells from mice constructed with a disruption in the Snm1 gene are sensitive to the DNA interstrand crosslinker, mitomycin (MMC), as indicated by increased radial formation following exposure. The mice reproduce normally and have normal life spans. However, a partial perinatal lethality, not seen in either homozygous mutant alone, can be noted when the Snm1 disruption is combined with a Fancd2 disruption. To explore the role of hSNM1 and its homologs in ICL repair in human cells, we used siRNA depletion in human fibroblasts, with cell survival and chromosome radials as the end points for sensitivity following treatment with MMC. Depletion of hSNM1 increases sensitivity to ICLs as detected by both end points, while depletion of Artemis does not. Thus hSNM1 is active in maintenance of genome stability following ICL formation. To evaluate the epistatic relationship between hSNM1 and other ICL repair pathways, we depleted hSNM1 in Fanconi anemia (FA) cells, which are inherently sensitive to ICLs. Depletion of hSNM1 in an FA cell line produces additive sensitivity for MMC. Further, mono-ubiquitination of FANCD2, an endpoint of the FA pathway, is not disturbed by depletion of hSNM1 in normal cells. Thus, hSNM1 appears to represent a second pathway for genome stability, distinct from the FA pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.