ArticleRespiratory research2008
Clara cell adhesion and migration to extracellular matrix.
Article in Respiratory research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 95 citations in OpenAlex.
- Harnessing fine fibers in decellularized adipose-derived matrix for enhanced adipose regeneration.Materials today. Bio · 2024Article
- Changes of collagen content in lung tissues of plateau yak and its mechanism of adaptation to hypoxia.PeerJ · 2024Article
- Collagen and Beyond: A Comprehensive Comparison of Human ECM Properties Derived from Various Tissue Sources for Regenerative Medicine Applications.Journal of functional biomaterials · 2023Article
- Bioinks of Natural Biomaterials for Printing Tissues.Bioengineering (Basel, Switzerland) · 2023Article
- Three-Dimensional Bioprinting of Decellularized Extracellular Matrix-Based Bioinks for Tissue Engineering.Molecules (Basel, Switzerland) · 2022Review
- The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease.Molecules (Basel, Switzerland) · 2020Review
- Preparation and Characterization of Human Adipose Tissue-Derived Extracellular Matrix, Growth Factors, and Stem Cells: A Concise Review.Tissue engineering and regenerative medicine · 2019Review
- Preparation and characterization of acellular adipose tissue matrix using a combination of physical and chemical treatments.Molecular medicine reports · 2018Article
- Generation of Induced Progenitor-like Cells from Mature Epithelial Cells Using Interrupted Reprogramming.Stem cell reports · 2017Article
- Serum Clara cell protein and atopic phenotype in children up to 2 years of age.Journal of clinical laboratory analysis · 2017Article
- Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis.Scientific reports · 2017Article
- Integrating Lung Physiology, Immunology, and Tuberculosis.Trends in microbiology · 2017Review
- Targeted proteomics effectively quantifies differences between native lung and detergent-decellularized lung extracellular matrices.Acta biomaterialia · 2016Article
- Acellular porcine corneal matrix as a carrier scaffold for cultivating human corneal epithelial cells and fibroblasts in vitro.International journal of ophthalmology · 2016Article
- Nano-TiO₂ particles impair adhesion of airway epithelial cells to fibronectin.Respiratory physiology & neurobiology · 2013Article
- CCAAT/enhancer binding protein-α regulates the protease/antiprotease balance required for bronchiolar epithelium regeneration.American journal of respiratory cell and molecular biology · 2012Article
- Relationship of metabolism and cell proliferation to the mode of action of fluensulfone-induced mouse lung tumors: analysis of their human relevance using the IPCS framework.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
- SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.The Journal of clinical investigation · 2012Article
- Autotaxin induces lung epithelial cell migration through lysoPLD activity-dependent and -independent pathways.The Biochemical journal · 2011Article
- Imbalance of Clara cell-mediated homeostatic inflammation is involved in lung metastasis.Oncogene · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundClara cells are the epithelial progenitor cell of the small airways, a location known to be important in many lung disorders. Although migration of alveolar type II and bronchiolar ciliated epithelial cells has been examined, the migratory response of Clara cells has received little attention.
methodsUsing a modification of existing procedures for Clara cell isolation, we examined mouse Clara cells and a mouse Clara-like cell line (C22) for adhesion to and migration toward matrix substrate gradients, to establish the nature and integrin dependence of migration in Clara cells.
resultsWe observed that Clara cells adhere preferentially to fibronectin (Fn) and type I collagen (Col I) similar to previous reports. Migration of Clara cells can be directed by a fixed gradient of matrix substrates (haptotaxis). Migration of the C22 cell line was similar to the Clara cells so integrin dependence of migration was evaluated with this cell line. As determined by competition with an RGD containing-peptide, migration of C22 cells toward Fn and laminin (Lm) 511 (formerly laminin 10) was significantly RGD integrin dependent, but migration toward Col I was RGD integrin independent, suggesting that Clara cells utilize different receptors for these different matrices.
conclusionThus, Clara cells resemble alveolar type II and bronchiolar ciliated epithelial cells by showing integrin mediated pro-migratory changes to extracellular matrix components that are present in tissues after injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.