ArticlePhotochemistry and photobiology
Promotion of PDT efficacy by a Bcl-2 antagonist.
Article in Photochemistry and photobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- The use of photodynamic therapy in medical practice.Frontiers in oncology · 2024Review
- Light-Activated Protoporphyrin IX-Based Polysilsesquioxane Nanoparticles Induce Ferroptosis in Melanoma Cells.Nanomaterials (Basel, Switzerland) · 2021Article
- An update in clinical utilization of photodynamic therapy for lung cancer.Journal of Cancer · 2021Review
- The Photomodulation Activity of Metformin Against Oral Microbiome.Journal of lasers in medical sciences · 2019Review
- MicroRNAs associated with the efficacy of photodynamic therapy in biliary tract cancer cell lines.International journal of molecular sciences · 2014Article
- Epidermal growth factor receptor-targeted photosensitizer selectively inhibits EGFR signaling and induces targeted phototoxicity in ovarian cancer cells.Cancer letters · 2012Article
- Verteporfin-based photodynamic therapy overcomes gemcitabine insensitivity in a panel of pancreatic cancer cell lines.Lasers in surgery and medicine · 2011Article
- Adventures in photodynamic therapy: 1976-2008.Journal of porphyrins and phthalocyanines · 2008Article
- The Bcl-2 antagonist HA14-1 forms a fluorescent albumin complex that can be mistaken for several oxidized ROS probes.Photochemistry and photobiologyArticle
- Photodynamic therapy of cancer: an update.CA: a cancer journal for cliniciansReview
- On the use of fluorescence probes for detecting reactive oxygen and nitrogen species associated with photodynamic therapy.Journal of biomedical opticsArticle
- A role for hydrogen peroxide in the pro-apoptotic effects of photodynamic therapy.Photochemistry and photobiologyArticle
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Photodynamic therapy (PDT) directed against the endoplasmic reticulum (ER) is also known to target antiapoptotic Bcl-2 family proteins. This effect is associated with the initiation of both apoptosis, a cell death pathway, and autophagy, an organelle recycling system that can lead to survival or cell death. In this study, we examined the ability of the Bcl-2 antagonist HA14-1 to promote the photodynamic efficacy of PDT directed at the ER. At concentrations that independently caused only a small loss of viability, HA14-1 markedly enhanced the proapoptotic and phototoxic effects of ER photodamage. These results provide additional evidence that the antiapoptotic properties of Bcl-2 constitute an important determinant of photokilling, and demonstrate that synergistic effects can result when PDT is coupled with pharmacologic suppression of Bcl-2 function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.