ArticleTwin research and human genetics : the official journal of the International Society for Twin Studies2007
Heritability of oral microbial species in caries-active and caries-free twins.
Article in Twin research and human genetics : the official journal of the International Society for Twin Studies, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Is the caregivers' oral health related to dental caries in children or adolescents? A systematic review.Clinical oral investigations · 2019Pooled it
- The dental plaque microbiome in health and disease.PloS one · 2013Trial
- Life stage shifts in salivary microbiota determinants: a cross-sectional study in twins.NPJ biofilms and microbiomes · 2026Article
- Estimates of microbiome heritability across hosts.Nature microbiology · 2024Review
- The Oral Microbial Ecosystem in Age-Related Xerostomia: A Critical Review.International journal of molecular sciences · 2024Review
- Secretome analysis and virulence assessment inJournal of oral microbiology · 2024Article
- Microbiome ownership for Indigenous peoples.Nature microbiology · 2023Review
- Ecology, Not Host Phylogeny, Shapes the Oral Microbiome in Closely Related Species.Molecular biology and evolution · 2022Article
- [Development and Influencing Factors of Oral Microbiota in Early Life].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022Review
- Silver diamine fluoride alters microbial communities in subsurface dentin.JADA foundational science · 2022Article
- Acquisition and establishment of the oral microbiota.Periodontology 2000 · 2021Review
- Biocultural Drivers of Salivary Microbiota in Australian Aboriginal and Torres Strait Islander Children.Frontiers in oral health · 2021Article
- A Review of the Role of Probiotic Supplementation in Dental Caries.Probiotics and antimicrobial proteins · 2020Review
- The role of the oral microbiota in chronic non-communicable disease and its relevance to the Indigenous health gap in Australia.BMC oral health · 2020Review
- Ethnic variation of oral microbiota in children.Scientific reports · 2020Article
- Heritability of Oral Microbiota and Immune Responses to Oral Bacteria.Microorganisms · 2020Article
- Longitudinal Study of Oral Microbiome Variation in Twins.Scientific reports · 2020Article
- Sociodemographic variation in the oral microbiome.Annals of epidemiology · 2019Article
- Oral microbiome and health.AIMS microbiology · 2018Review
- Host Genetic Control of the Oral Microbiome in Health and Disease.Cell host & microbe · 2017Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
Oral microbes that colonize in the mouths of humans contribute to disease susceptibility, but it is unclear if host genetic factors mediate colonization. We therefore tested the hypothesis that the levels at which oral microbes colonize in the mouth are heritable. Dental plaque biofilms were sampled from intact tooth surfaces of 118 caries-free twins. An additional 86 caries-active twins were sampled for plaque from carious lesions and intact tooth surfaces. Using a reverse capture checkerboard assay the relative abundance of 82 bacterial species was determined. An integrative computational predictive model determined microbial abundance patterns of microbial species in caries-free twins as compared to caries-active twins. Heritability estimates were calculated for the relative microbial abundance levels of the microbial species in both groups. The levels of 10 species were significantly different in healthy individuals than in caries-active individuals, including, A. defectiva, S. parasanguinis, S. mitis/oralis, S. sanguinis, S. cristatus, S. salivarius, Streptococcus sp. clone CH016, G. morbillorum and G. haemolysans. Moderate to high heritability estimates were found for these species (h(2) = 56%-80%, p < .0001). Similarity of the overall oral microbial flora was also evident in caries-free twins from multivariate distance matrix regression analysis. It appears that genetic and/or familial factors significantly contribute to the colonization of oral beneficial species in twins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.