ArticleThe Journal of infectious diseases2008
Lysogenic transfer of group A Streptococcus superantigen gene among Streptococci.
Article in The Journal of infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Survival Strategies ofViruses · 2021Article
- Genome Analysis of Streptococcus pyogenes Associated with Pharyngitis and Skin Infections.PloS one · 2016Article
- Natural solution to antibiotic resistance: bacteriophages 'The Living Drugs'.World journal of microbiology & biotechnology · 2014Review
- Evolutionary paths of streptococcal and staphylococcal superantigens.BMC genomics · 2012Article
- Streptococcus pyogenes and re-emergence of scarlet fever as a public health problem.Emerging microbes & infections · 2012Review
- The structural characterization of a prophage-encoded extracellular DNase from Streptococcus pyogenes.Nucleic acids research · 2012Article
- Pathogenic characterization of a cervical lymph node derived from a patient with Kawasaki disease.International journal of clinical and experimental pathology · 2012Article
- Beta-hemolytic streptococcal erythroderma syndrome: a clinical and pathogenic analysis.The American journal of the medical sciences · 2011Article
- Virulence gene pool detected in bovine group C Streptococcus dysgalactiae subsp. dysgalactiae isolates by use of a group A S. pyogenes virulence microarray.Journal of clinical microbiology · 2011Article
- Article
- Metagenomic detection of phage-encoded platelet-binding factors in the human oral cavity.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Lysogenic transfer of mef(A) and tet(O) genes carried by Phim46.1 among group A streptococci.Antimicrobial agents and chemotherapy · 2010Article
- Heat shock proteins and superantigenic properties of bacteria from the gastrointestinal tract of patients with Kawasaki disease.Immunology · 2009Article
- Genetic relationships deduced from emm and multilocus sequence typing of invasive Streptococcus dysgalactiae subsp. equisimilis and S. canis recovered from isolates collected in the United States.Journal of clinical microbiology · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
A group A Streptococcus (GAS) isolate, serotype M12, recovered from a patient with streptococcal toxic shock syndrome was analyzed for superantigen-carrying prophages, revealing phi149, which encodes superantigen SSA. Sequence analysis of the att-L proximal region of phi149 showed that the phage had a mosaic nature. Remarkably, we successfully obtained lysogenic conversion of GAS clinical isolates of various M serotypes (M1, M3, M5, M12, M19, M28, and M94), as well as of group C Streptococcus equisimilis (GCSE) clinical isolates, via transfer of a recombinant phage phi149::Km(r). Phage phi149::Km(r) from selected lysogenized GAS and GCSE strains could be transferred back to M12 GAS strains. Our data indicate that horizontal transfer of lysogenic phages among GAS can occur across the M-type barrier; these data also provide further support for the hypothesis that toxigenic conversion can occur via lysogeny between species. Streptococci might employ this mechanism specifically to allow more efficient adaptation to changing host challenges, potentially leading to fitter and more virulent clones.
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Registered trials
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