ArticlePLoS computational biology2008
Noise propagation and signaling sensitivity in biological networks: a role for positive feedback.
Article in PLoS computational biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
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Who cites it
94 citing papers in PubMed, 211 citations in OpenAlex.
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- Deduction of signaling mechanisms from cellular responses to multiple cues.NPJ systems biology and applications · 2022Article
- Network design principle for robust oscillatory behaviors with respect to biological noise.eLife · 2022Article
- Parameterising Translational Feedback Models of Autoregulatory RNA-Binding Proteins inMicroorganisms · 2022Article
- Mathematical Modelling in Plant Synthetic Biology.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Computational analysis of GAL pathway pinpoints mechanisms underlying natural variation.PLoS computational biology · 2021Article
- A self-exciting point process to study multicellular spatial signaling patterns.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Stochastic Simulations as a Tool for Assessing Signal Fidelity in Gene Expression in Synthetic Promoter Design.Biology · 2021Article
- Noise suppression in stochastic genetic circuits using PID controllers.PLoS computational biology · 2021Article
- Role of integrated noise in pathway-specific signal propagation in feed-forward loops.Theory in biosciences = Theorie in den Biowissenschaften · 2021Article
- Finding gene network topologies for given biological function with recurrent neural network.Nature communications · 2021Article
- Stability Analysis of a Signaling Circuit with Dual Species of GTPase Switches.Bulletin of mathematical biology · 2021Article
34 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Interactions between genes and proteins are crucial for efficient processing of internal or external signals, but this connectivity also amplifies stochastic fluctuations by propagating noise between components. Linear (unbranched) cascades were shown to exhibit an interplay between the sensitivity to changes in input signals and the ability to buffer noise. We searched for biological circuits that can maintain signaling sensitivity while minimizing noise propagation, focusing on cases where the noise is characterized by rapid fluctuations. Negative feedback can buffer this type of noise, but this buffering comes at the expense of an even greater reduction in signaling sensitivity. By systematically analyzing three-component circuits, we identify positive feedback as a central motif allowing for the buffering of propagated noise while maintaining sensitivity to long-term changes in input signals. We show analytically that noise reduction in the presence of positive feedback results from improved averaging of rapid fluctuations over time, and discuss in detail a particular implementation in the control of nutrient homeostasis in yeast. As the design of biological networks optimizes for multiple constraints, positive feedback can be used to improve sensitivity without a compromise in the ability to buffer propagated noise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.