ArticlePLoS computational biology2008
Chemotaxis in Escherichia coli: a molecular model for robust precise adaptation.
Article in PLoS computational biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 197 citations in OpenAlex.
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- Bacterial Adaptation to Radiofrequency Electromagnetic Fields Based on Experiences from Ionizing Radiation.Journal of biomedical physics & engineering · 2026Review
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- A flagellar accessory protein links chemotaxis to surface sensing.Journal of bacteriology · 2024Article
- A flagellar accessory protein links chemotaxis to surface sensing.bioRxiv : the preprint server for biology · 2024Article
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- Chemorepellent-Loaded Nanocarriers Promote Localized Interference ofACS applied bio materials · 2022Article
- Parallel Evolution towards Increased Motility in Long-Term Cultures of Escherichia coli, Even Though Motility was Not Required for Long-Term Survival.Microbiology spectrum · 2022Article
- Ras inhibitor CAPRI enables neutrophil-like cells to chemotax through a higher-concentration range of gradients.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Sequential modification of bacterial chemoreceptors is key for achieving both accurate adaptation and high gain.Nature communications · 2020Article
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- Combinatorial Control through Allostery.The journal of physical chemistry. B · 2019Article
- Using Bacterial Transcriptomics to Investigate Targets of Host-Bacterial Interactions in Caenorhabditis elegans.Scientific reports · 2019Article
- Behavioral Variability and Phenotypic Diversity in Bacterial Chemotaxis.Annual review of biophysics · 2018Review
- Mathematical Analysis of the Escherichia coli Chemotaxis Signalling Pathway.Bulletin of mathematical biology · 2018Article
- Motor Adaptive Remodeling Speeds Up Bacterial Chemotactic Adaptation.Biophysical journal · 2018Article
- Article
- Propulsion and Chemotaxis in Bacteria-Driven Microswimmers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2017Article
- Mechanism of bidirectional thermotaxis ineLife · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The chemotaxis system in the bacterium Escherichia coli is remarkably sensitive to small relative changes in the concentrations of multiple chemical signals over a broad range of ambient concentrations. Interactions among receptors are crucial to this sensitivity as is precise adaptation, the return of chemoreceptor activity to prestimulus levels in a constant chemoeffector environment. Precise adaptation relies on methylation and demethylation of chemoreceptors by the enzymes CheR and CheB, respectively. Experiments indicate that when transiently bound to one receptor, these enzymes act on small assistance neighborhoods (AN) of five to seven receptor homodimers. In this paper, we model a strongly coupled complex of receptors including dynamic CheR and CheB acting on ANs. The model yields sensitive response and precise adaptation over several orders of magnitude of attractant concentrations and accounts for different responses to aspartate and serine. Within the model, we explore how the precision of adaptation is limited by small AN size as well as by CheR and CheB kinetics (including dwell times, saturation, and kinetic differences among modification sites) and how these kinetics contribute to noise in complex activity. The robustness of our dynamic model for precise adaptation is demonstrated by randomly varying biochemical parameters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.